Detalles de la búsqueda
1.
Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study.
J Clin Psychopharmacol
; 43(2): 113-121, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-36700734
2.
Phase I studies of the safety, tolerability, pharmacokinetics and pharmacodynamics of the dual glucagon receptor/glucagon-like peptide-1 receptor agonist BI 456906.
Diabetes Obes Metab
; 25(4): 1011-1023, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36527386
3.
Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia.
Eur Arch Psychiatry Clin Neurosci
; 273(7): 1557-1566, 2023 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36971864
4.
Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression.
J Biol Chem
; 287(29): 24483-91, 2012 Jul 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-22645148
5.
Identification of ATF2 as a transcriptional regulator of renin gene.
Biol Chem
; 393(1-2): 93-100, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-22628303
6.
The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]-BI 425809 in Healthy Males.
Clin Drug Investig
; 42(1): 87-99, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34936055
7.
Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
Eur J Drug Metab Pharmacokinet
; 47(1): 91-103, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34716565
8.
cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Pflugers Arch
; 461(5): 567-77, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21424707
9.
Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study.
Lancet Psychiatry
; 8(3): 191-201, 2021 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-33610228
10.
Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Am J Physiol Renal Physiol
; 299(2): F396-403, 2010 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-20519377
11.
The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by peroxisome proliferator-activated receptor-gamma.
Endocrinology
; 149(9): 4647-57, 2008 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-18483152
12.
Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study.
Eur J Drug Metab Pharmacokinet
; 43(2): 239-249, 2018 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-29076028
13.
Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics.
Clin Drug Investig
; 38(8): 737-750, 2018 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-29846887
14.
Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.
Clin Transl Sci
; 11(6): 616-623, 2018 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30136756
15.
Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [14C]BI 425809 in Healthy Males.
Clin Drug Investig
; 42(4): 375, 2022 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-35286627
16.
PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.
Mol Endocrinol
; 24(11): 2139-51, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20861226
17.
Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Hypertension
; 55(3): 660-6, 2010 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-20065157
18.
Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.
Hypertension
; 50(5): 939-44, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17785633
19.
Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
J Am Soc Nephrol
; 18(4): 1150-6, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17360952
Resultados
1 -
19
de 19
1
Próxima >
>>