Detalles de la búsqueda
1.
GSK3640254 Is a Novel HIV-1 Maturation Inhibitor with an Optimized Virology Profile.
Antimicrob Agents Chemother
; 66(1): e0187621, 2022 01 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34780263
2.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35605346
3.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33508465
4.
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bioorg Med Chem Lett
; 30(3): 126784, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31761656
5.
Design, synthesis and SAR study of bridged tricyclic pyrimidinone carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem
; 28(13): 115541, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32389483
6.
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
PLoS Pathog
; 12(11): e1005990, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27893830
7.
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Bioorg Med Chem Lett
; 28(12): 2124-2130, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29779976
8.
The design, synthesis and structure-activity relationships associated with C28 amine-based betulinic acid derivatives as inhibitors of HIV-1 maturation.
Bioorg Med Chem Lett
; 28(9): 1550-1557, 2018 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-29631960
9.
Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).
Clin Infect Dis
; 65(3): 442-452, 2017 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28369211
10.
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Antimicrob Agents Chemother
; 60(7): 3956-69, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27090171
11.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26988305
12.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26968652
13.
Homology models of the HIV-1 attachment inhibitor BMS-626529 bound to gp120 suggest a unique mechanism of action.
Proteins
; 83(2): 331-50, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25401969
14.
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 25(3): 717-20, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25529736
15.
In vitro cross-resistance profile of nucleoside reverse transcriptase inhibitor (NRTI) BMS-986001 against known NRTI resistance mutations.
Antimicrob Agents Chemother
; 57(11): 5500-8, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23979732
16.
In vitro antiviral characteristics of HIV-1 attachment inhibitor BMS-626529, the active component of the prodrug BMS-663068.
Antimicrob Agents Chemother
; 56(7): 3498-507, 2012 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-22547625
17.
Synthesis, Structure-Activity Relationships, and In Vivo Evaluation of Novel C-17 Amine Derivatives Based on GSK3640254 as HIV-1 Maturation Inhibitors with Broad Spectrum Activity.
J Med Chem
; 65(23): 15935-15966, 2022 12 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-36441509
18.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett
; 13(6): 972-980, 2022 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35707159
19.
The Discovery of GSK3640254, a Next-Generation Inhibitor of HIV-1 Maturation.
J Med Chem
; 65(18): 11927-11948, 2022 09 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-36044257
20.
Solid phase synthesis of novel pyrrolidinedione analogs as potent HIV-1 integrase inhibitors.
J Comb Chem
; 12(1): 84-90, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-19902958