Detalles de la búsqueda
1.
Scaffold modifications to the 4-(4,4-dimethylpiperidinyl) 2,6-dimethylpyridinyl class of HIV-1 allosteric integrase inhibitors.
Bioorg Med Chem
; 67: 116833, 2022 08 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35605346
2.
Design and exploration of C-3 benzoic acid bioisosteres and alkyl replacements in the context of GSK3532795 (BMS-955176) that exhibit broad spectrum HIV-1 maturation inhibition.
Bioorg Med Chem Lett
; 36: 127823, 2021 03 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33508465
3.
Heterocycle amide isosteres: An approach to overcoming resistance for HIV-1 integrase strand transfer inhibitors.
Bioorg Med Chem Lett
; 30(3): 126784, 2020 02 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31761656
4.
Mechanistic Studies and Modeling Reveal the Origin of Differential Inhibition of Gag Polymorphic Viruses by HIV-1 Maturation Inhibitors.
PLoS Pathog
; 12(11): e1005990, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27893830
5.
The discovery and preclinical evaluation of BMS-707035, a potent HIV-1 integrase strand transfer inhibitor.
Bioorg Med Chem Lett
; 28(12): 2124-2130, 2018 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29779976
6.
Antiviral Activity, Safety, and Exposure-Response Relationships of GSK3532795, a Second-Generation Human Immunodeficiency Virus Type 1 Maturation Inhibitor, Administered as Monotherapy or in Combination With Atazanavir With or Without Ritonavir in a Phase 2a Randomized, Dose-Ranging, Controlled Trial (AI468002).
Clin Infect Dis
; 65(3): 442-452, 2017 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-28369211
7.
Identification and Characterization of BMS-955176, a Second-Generation HIV-1 Maturation Inhibitor with Improved Potency, Antiviral Spectrum, and Gag Polymorphic Coverage.
Antimicrob Agents Chemother
; 60(7): 3956-69, 2016 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-27090171
8.
Inhibitors of HIV-1 maturation: Development of structure-activity relationship for C-28 amides based on C-3 benzoic acid-modified triterpenoids.
Bioorg Med Chem Lett
; 26(8): 1925-30, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26988305
9.
C-3 benzoic acid derivatives of C-3 deoxybetulinic acid and deoxybetulin as HIV-1 maturation inhibitors.
Bioorg Med Chem
; 24(8): 1757-70, 2016 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26968652
10.
Synthesis and evaluation of C2-carbon-linked heterocyclic-5-hydroxy-6-oxo-dihydropyrimidine-4-carboxamides as HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 25(3): 717-20, 2015 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25529736
11.
Discovery and Preclinical Profiling of GSK3839919, a Potent HIV-1 Allosteric Integrase Inhibitor.
ACS Med Chem Lett
; 13(6): 972-980, 2022 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35707159
12.
Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors.
J Med Chem
; 63(5): 2620-2637, 2020 03 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-32081010
13.
Second Generation Inhibitors of HIV-1 Maturation.
ACS Med Chem Lett
; 10(3): 287-294, 2019 Mar 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30891128
14.
The terminal (catalytic) adenosine of the HIV LTR controls the kinetics of binding and dissociation of HIV integrase strand transfer inhibitors.
Biochemistry
; 47(51): 13481-8, 2008 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-18991395
15.
Safety, efficacy, and dose response of the maturation inhibitor GSK3532795 (formerly known as BMS-955176) plus tenofovir/emtricitabine once daily in treatment-naive HIV-1-infected adults: Week 24 primary analysis from a randomized Phase IIb trial.
PLoS One
; 13(10): e0205368, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30352054
16.
Design, Synthesis, and SAR of C-3 Benzoic Acid, C-17 Triterpenoid Derivatives. Identification of the HIV-1 Maturation Inhibitor 4-((1 R,3a S,5a R,5b R,7a R,11a S,11b R,13a R,13b R)-3a-((2-(1,1-Dioxidothiomorpholino)ethyl)amino)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1 H-cyclopenta[ a]chrysen-9-yl)benzoic Acid (GSK3532795, BMS-955176).
J Med Chem
; 61(16): 7289-7313, 2018 08 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-30067361
17.
Discovery of BMS-955176, a Second Generation HIV-1 Maturation Inhibitor with Broad Spectrum Antiviral Activity.
ACS Med Chem Lett
; 7(6): 568-72, 2016 Jun 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27326328
18.
Inhibitors of human immunodeficiency virus type 1 (HIV-1) attachment. 5. An evolution from indole to azaindoles leading to the discovery of 1-(4-benzoylpiperazin-1-yl)-2-(4,7-dimethoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)ethane-1,2-dione (BMS-488043), a drug candidate that demonstrates antiviral activity in HIV-1-infected subjects.
J Med Chem
; 52(23): 7778-87, 2009 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-19769332
19.
Biochemical analysis of HIV-1 integrase variants resistant to strand transfer inhibitors.
J Biol Chem
; 283(35): 23599-609, 2008 Aug 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-18577511
20.
Changes to the HIV long terminal repeat and to HIV integrase differentially impact HIV integrase assembly, activity, and the binding of strand transfer inhibitors.
J Biol Chem
; 282(43): 31186-96, 2007 Oct 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-17715137