Detalles de la búsqueda
1.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors.
Nature
; 550(7677): 481-486, 2017 10 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29045389
2.
Discovery of MK-1832, a Kv1.5 inhibitor with improved selectivity and pharmacokinetics.
Bioorg Med Chem Lett
; 27(4): 1062-1069, 2017 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28131713
3.
Structure-based design and development of (benz)imidazole pyridones as JAK1-selective kinase inhibitors.
Bioorg Med Chem Lett
; 26(7): 1803-8, 2016 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26927423
4.
The discovery of reverse tricyclic pyridone JAK2 inhibitors. Part 2: lead optimization.
Bioorg Med Chem Lett
; 24(6): 1466-71, 2014 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24582987
5.
USP28 deletion and small-molecule inhibition destabilizes c-MYC and elicits regression of squamous cell lung carcinoma.
Elife
; 102021 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34636321
6.
The discovery of tricyclic pyridone JAK2 inhibitors. Part 1: hit to lead.
Bioorg Med Chem Lett
; 20(24): 7421-5, 2010 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21044843
7.
Discovery of triarylethanolamine inhibitors of the Kv1.5 potassium channel.
Bioorg Med Chem Lett
; 20(8): 2493-6, 2010 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20304642
8.
Structure-Based Design and Identification of FT-2102 (Olutasidenib), a Potent Mutant-Selective IDH1 Inhibitor.
J Med Chem
; 63(4): 1612-1623, 2020 02 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31971798
9.
Preparation of a stable trifluoroborate salt for the synthesis of 1-aryl-2,2-difluoro-enolethers and/or 2,2-difluoro-1-aryl-ketones via palladium-mediated cross-coupling.
J Org Chem
; 74(22): 8866-9, 2009 Nov 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-19845317
10.
Atrial antifibrillatory effects of structurally distinct IKur blockers 3-[(dimethylamino)methyl]-6-methoxy-2-methyl-4-phenylisoquinolin-1(2H)-one and 2-phenyl-1,1-dipyridin-3-yl-2-pyrrolidin-1-yl-ethanol in dogs with underlying heart failure.
J Pharmacol Exp Ther
; 324(1): 322-30, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-17967939
11.
The Discovery of 3-((4-Chloro-3-methoxyphenyl)amino)-1-((3R,4S)-4-cyanotetrahydro-2H-pyran-3-yl)-1H-pyrazole-4-carboxamide, a Highly Ligand Efficient and Efficacious Janus Kinase 1 Selective Inhibitor with Favorable Pharmacokinetic Properties.
J Med Chem
; 60(23): 9676-9690, 2017 12 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-29156136
12.
Design and synthesis of novel isoquinoline-3-nitriles as orally bioavailable Kv1.5 antagonists for the treatment of atrial fibrillation.
J Med Chem
; 49(24): 6954-7, 2006 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-17125248
13.
Inhibitors of farnesyltransferase and geranylgeranyltransferase-I for antitumor therapy: substrate-based design, conformational constraint and biological activity.
Curr Top Med Chem
; 3(10): 1075-93, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12769709
14.
Carboxylation and Mitsunobu reaction of amines to give carbamates: retention vs inversion of configuration is substituent-dependent.
Org Lett
; 6(17): 2885-8, 2004 Aug 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15330639
15.
Preparation of substituted piperazinones via tandem reductive amination-(N,N'-acyl transfer)-cyclization.
Org Lett
; 4(7): 1201-4, 2002 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11922818
16.
Nonconventional Stereochemical Issues in the Design of the Synthesis of the Vancomycin Antibiotics: Challenges Imposed by Axial and Nonplanar Chiral Elements in the Heptapeptide Aglycons.
Angew Chem Int Ed Engl
; 37(19): 2704-2708, 1998 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29711602
17.
Discovery of 1-[3-(1-methyl-1H-pyrazol-4-yl)-5-oxo-5H-benzo[4,5]cyclohepta[1,2-b]pyridin-7-yl]-N-(pyridin-2-ylmethyl)methanesulfonamide (MK-8033): A Specific c-Met/Ron dual kinase inhibitor with preferential affinity for the activated state of c-Met.
J Med Chem
; 56(6): 2294-310, 2013 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23379595
18.
Discovery of 1-amino-5H-pyrido[4,3-b]indol-4-carboxamide inhibitors of Janus kinase 2 (JAK2) for the treatment of myeloproliferative disorders.
J Med Chem
; 54(20): 7334-49, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21942426
19.
Discovery of a 5H-benzo[4,5]cyclohepta[1,2-b]pyridin-5-one (MK-2461) inhibitor of c-Met kinase for the treatment of cancer.
J Med Chem
; 54(12): 4092-108, 2011 Jun 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-21608528
20.
Parallel synthesis of ureas and carbamates from amines and CO2 under mild conditions.
Org Lett
; 12(6): 1340-3, 2010 Mar 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-20175533