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In vitro metabolism studies on the isoxazole ring scission in the anti-inflammatory agent lefluonomide to its active alpha-cyanoenol metabolite A771726: mechanistic similarities with the cytochrome P450-catalyzed dehydration of aldoximes.
Drug Metab Dispos
; 31(10): 1240-50, 2003 Oct.
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| MEDLINE | ID: mdl-12975333
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