Detalles de la búsqueda
1.
Synthesis and evaluation of carbamoylmethylene linked prodrugs of BMS-582949, a clinical p38α inhibitor.
Bioorg Med Chem Lett
; 23(10): 3028-33, 2013 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23578688
2.
Synthesis and structure-activity relationships of novel indazolyl glucocorticoid receptor partial agonists.
Bioorg Med Chem Lett
; 23(19): 5448-51, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23916594
3.
The identification of novel p38α isoform selective kinase inhibitors having an unprecedented p38α binding mode.
Bioorg Med Chem Lett
; 23(14): 4120-6, 2013 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23746475
4.
Discovery of potent and selective nonsteroidal indazolyl amide glucocorticoid receptor agonists.
Bioorg Med Chem Lett
; 23(19): 5442-7, 2013 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23953070
5.
Discovery of pyrrolo[2,1-f][1,2,4]triazine C6-ketones as potent, orally active p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 21(15): 4633-7, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21705217
6.
Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis.
Bioorg Med Chem Lett
; 21(1): 383-6, 2011 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21087862
7.
Novel tricyclic inhibitors of IKK2: discovery and SAR leading to the identification of 2-methoxy-N-((6-(1-methyl-4-(methylamino)-1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-7-yl)pyridin-2-yl)methyl)acetamide (BMS-066).
Bioorg Med Chem Lett
; 21(23): 7006-12, 2011 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22018461
8.
Utilization of a nitrogen-sulfur nonbonding interaction in the design of new 2-aminothiazol-5-yl-pyrimidines as p38α MAP kinase inhibitors.
Bioorg Med Chem Lett
; 20(19): 5864-8, 2010 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20732813
9.
5-amino-pyrazoles as potent and selective p38α inhibitors.
Bioorg Med Chem Lett
; 20(23): 6886-9, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21035336
10.
Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase.
Bioorg Med Chem Lett
; 19(10): 2646-9, 2009 May 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19376699
11.
Benzothiazole based inhibitors of p38alpha MAP kinase.
Bioorg Med Chem Lett
; 18(6): 1874-9, 2008 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18296051
12.
Pyrazolo-pyrimidines: a novel heterocyclic scaffold for potent and selective p38 alpha inhibitors.
Bioorg Med Chem Lett
; 18(8): 2652-7, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18359226
13.
5-Cyanopyrimidine derivatives as a novel class of potent, selective, and orally active inhibitors of p38alpha MAP kinase.
J Med Chem
; 48(20): 6261-70, 2005 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-16190753
14.
Discovery of ((4-(5-(Cyclopropylcarbamoyl)-2-methylphenylamino)-5-methylpyrrolo[1,2-f][1,2,4]triazine-6-carbonyl)(propyl)carbamoyloxy)methyl-2-(4-(phosphonooxy)phenyl)acetate (BMS-751324), a Clinical Prodrug of p38α MAP Kinase Inhibitor.
J Med Chem
; 58(19): 7775-84, 2015 Oct 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-26359680
15.
Azaxanthene based selective glucocorticoid receptor modulators: design, synthesis, and pharmacological evaluation of (S)-4-(5-(1-((1,3,4-thiadiazol-2-yl)amino)-2-methyl-1-oxopropan-2-yl)-5H-chromeno[2,3-b]pyridin-2-yl)-2-fluoro-N,N-dimethylbenzamide (BMS-776532) and its methylene homologue (BMS-791826).
J Med Chem
; 54(20): 7318-33, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21899328
16.
Novel synthesis of the hexahydroimidazo[1,5b]isoquinoline scaffold: application to the synthesis of glucocorticoid receptor modulators.
J Med Chem
; 53(3): 1270-80, 2010 Feb 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20047280
17.
Dimethyl-diphenyl-propanamide derivatives as nonsteroidal dissociated glucocorticoid receptor agonists.
J Med Chem
; 53(23): 8241-51, 2010 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21073190
18.
Discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-N-propylpyrrolo[1,2-f][1,2,4]triazine-6-carboxamide (BMS-582949), a clinical p38α MAP kinase inhibitor for the treatment of inflammatory diseases.
J Med Chem
; 53(18): 6629-39, 2010 Sep 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-20804198
19.
Novel tricyclic inhibitors of IkappaB kinase.
J Med Chem
; 52(7): 1994-2005, 2009 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-19267461
20.
Synthesis and SAR of p38alpha MAP kinase inhibitors based on heterobicyclic scaffolds.
Bioorg Med Chem Lett
; 17(18): 5019-24, 2007 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17664068