Detalles de la búsqueda
1.
Novel neuroactive steroids as positive allosteric modulators of NMDA receptors: mechanism, site of action, and rescue pharmacology on GRIN variants associated with neurological conditions.
Cell Mol Life Sci
; 80(2): 42, 2023 Jan 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36645496
2.
Trial of SAGE-217 in Patients with Major Depressive Disorder.
N Engl J Med
; 381(10): 903-911, 2019 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31483961
3.
Oxysterols Modulate the Acute Effects of Ethanol on Hippocampal N-Methyl-d-Aspartate Receptors, Long-Term Potentiation, and Learning.
J Pharmacol Exp Ther
; 377(1): 181-188, 2021 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-33441369
4.
Metabotropic, but not allosteric, effects of neurosteroids on GABAergic inhibition depend on the phosphorylation of GABAA receptors.
J Biol Chem
; 294(32): 12220-12230, 2019 08 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-31239352
5.
25-Hydroxycholesterol amplifies microglial IL-1ß production in an apoE isoform-dependent manner.
J Neuroinflammation
; 17(1): 192, 2020 Jun 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-32552741
6.
Brexanolone as adjunctive therapy in super-refractory status epilepticus.
Ann Neurol
; 82(3): 342-352, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28779545
7.
The synthetic neuroactive steroid SGE-516 reduces status epilepticus and neuronal cell death in a rat model of soman intoxication.
Epilepsy Behav
; 68: 22-30, 2017 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28109985
8.
Rescue of deficient amygdala tonic γ-aminobutyric acidergic currents in the Fmr-/y mouse model of fragile X syndrome by a novel γ-aminobutyric acid type A receptor-positive allosteric modulator.
J Neurosci Res
; 94(6): 568-78, 2016 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-26308557
9.
EEG-ß/γ spectral power elevation in rat: a translatable biomarker elicited by GABA(Aα2/3)-positive allosteric modulators at nonsedating anxiolytic doses.
J Neurophysiol
; 113(1): 116-31, 2015 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25253471
10.
The major brain cholesterol metabolite 24(S)-hydroxycholesterol is a potent allosteric modulator of N-methyl-D-aspartate receptors.
J Neurosci
; 33(44): 17290-300, 2013 Oct 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-24174662
11.
Pharmacological characterization of SAGE-718, a novel positive allosteric modulator of N-methyl-d-aspartate receptors.
Br J Pharmacol
; 181(7): 1028-1050, 2024 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-37698384
12.
Preventing Phosphorylation of the GABA A R ß3 Subunit Compromises the Behavioral Effects of Neuroactive Steroids.
Front Mol Neurosci
; 15: 817996, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35431797
13.
SAGE-718: A First-in-Class N-Methyl-d-Aspartate Receptor Positive Allosteric Modulator for the Potential Treatment of Cognitive Impairment.
J Med Chem
; 65(13): 9063-9075, 2022 07 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-35785990
14.
Stimulus-specific adaptation in auditory cortex is an NMDA-independent process distinct from the sensory novelty encoded by the mismatch negativity.
J Neurosci
; 30(49): 16475-84, 2010 Dec 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21147987
15.
A selective allosteric potentiator of the M1 muscarinic acetylcholine receptor increases activity of medial prefrontal cortical neurons and restores impairments in reversal learning.
J Neurosci
; 29(45): 14271-86, 2009 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-19906975
16.
Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABAA receptor positive allosteric modulator.
Neuropharmacology
; 181: 108333, 2020 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32976892
17.
Neuroactive Steroids Reverse Tonic Inhibitory Deficits in Fragile X Syndrome Mouse Model.
Front Mol Neurosci
; 12: 15, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30804752
18.
Neuroactive Steroid N-Methyl-d-aspartate Receptor Positive Allosteric Modulators: Synthesis, SAR, and Pharmacological Activity.
J Med Chem
; 62(16): 7526-7542, 2019 08 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-31390523
19.
The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model.
Sci Rep
; 7(1): 15327, 2017 11 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29127345
20.
Endogenous and synthetic neuroactive steroids evoke sustained increases in the efficacy of GABAergic inhibition via a protein kinase C-dependent mechanism.
Neuropharmacology
; 113(Pt A): 314-322, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27743930