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1.
Golexanolone improves fatigue, motor incoordination and gait and memory in rats with bile duct ligation.
Liver Int
; 44(2): 433-445, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-38010893
2.
The GABA system, a new target for medications against cognitive impairment-Associated with neuroactive steroids.
J Intern Med
; 294(3): 281-294, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37518841
3.
A pilot study of golexanolone, a new GABA-A receptor-modulating steroid antagonist, in patients with covert hepatic encephalopathy.
J Hepatol
; 75(1): 98-107, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33894327
4.
GR3027 antagonizes GABAA receptor-potentiating neurosteroids and restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy.
Am J Physiol Gastrointest Liver Physiol
; 309(5): G400-9, 2015 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26138462
5.
Allopregnanolone and its antagonist modulate neuroinflammation and neurological impairment.
Neurosci Biobehav Rev
; 161: 105668, 2024 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-38608826
6.
Neuroinflammation alters GABAergic neurotransmission in hyperammonemia and hepatic encephalopathy, leading to motor incoordination. Mechanisms and therapeutic implications.
Front Pharmacol
; 15: 1358323, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38560359
7.
Extra-Synaptic GABAA Receptor Potentiation and Neurosteroid-Induced Learning Deficits Are Inhibited by GR3027, a GABAA Modulating Steroid Antagonist.
Biomolecules
; 13(10)2023 10 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37892178
8.
Golexanolone, a GABAA receptor modulating steroid antagonist, restores motor coordination and cognitive function in hyperammonemic rats by dual effects on peripheral inflammation and neuroinflammation.
CNS Neurosci Ther
; 28(11): 1861-1874, 2022 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-35880480
9.
Neurosteroid Activation of GABA-A Receptors: A Potential Treatment Target for Symptoms in Primary Biliary Cholangitis?
Can J Gastroenterol Hepatol
; 2022: 3618090, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-36523650
10.
GR3027 reversal of neurosteroid-induced, GABA-A receptor-mediated inhibition of human brain function: an allopregnanolone challenge study.
Psychopharmacology (Berl)
; 235(5): 1533-1543, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29492615
11.
Baculovirus-mediated gene transfer and recombinant protein expression do not interfere with insulin dependent phosphorylation of PKB/Akt in human SHSY-5Y and C3A cells.
BMC Cell Biol
; 8: 6, 2007 Feb 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-17309805
12.
Acceleration of Amyloidosis by Inflammation in the Amyloid-Beta Marmoset Monkey Model of Alzheimer's Disease.
J Alzheimers Dis
; 55(1): 101-113, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27662314
13.
GABAA receptor modulating steroid antagonists (GAMSA) are functional in vivo.
J Steroid Biochem Mol Biol
; 160: 98-105, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26523675
14.
Effect of glycine on the cell yield and growth rate of Escherichia coli: evidence for cell-density-dependent glycine degradation as determined by (13)C NMR spectroscopy.
J Biotechnol
; 92(3): 237-49, 2002 Jan 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-11689248
15.
Membrane protein isolation by in situ solubilization, partitioning and affinity adsorption in aqueous two-phase systems. Purification of the human type 1 11beta-hydroxysteroid dehydrogenase.
J Chromatogr A
; 1043(2): 217-23, 2004 Jul 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-15330095
16.
Production of a truncated soluble human semicarbazide-sensitive amine oxidase mediated by a GST-fusion protein secreted from HEK293 cells.
Protein Expr Purif
; 46(2): 321-31, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16325418
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