Detalles de la búsqueda
1.
Sphingosine-1-Phosphate (S1P) Lyase Inhibition Causes Increased Cardiac S1P Levels and Bradycardia in Rats.
J Pharmacol Exp Ther
; 359(1): 151-8, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27519818
2.
Synthesis and optimization of furano[3,2-d]pyrimidines as selective spleen tyrosine kinase (Syk) inhibitors.
Bioorg Med Chem Lett
; 26(22): 5562-5567, 2016 11 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27789138
3.
Discovery of Small Molecule Interleukin 17A Inhibitors with Novel Binding Mode and Stoichiometry: Optimization of DNA-Encoded Chemical Library Hits to In Vivo Active Compounds.
J Med Chem
; 67(8): 6456-6494, 2024 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-38574366
4.
Characterization of digoxin uptake in sandwich-cultured human hepatocytes.
Drug Metab Dispos
; 39(1): 47-53, 2011 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-20926619
5.
pH-sensitive interaction of HMG-CoA reductase inhibitors (statins) with organic anion transporting polypeptide 2B1.
Mol Pharm
; 8(4): 1303-13, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21710988
6.
Discovery of novel hepatoselective HMG-CoA reductase inhibitors for treating hypercholesterolemia: a bench-to-bedside case study on tissue selective drug distribution.
Bioorg Med Chem Lett
; 21(9): 2725-31, 2011 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21183342
7.
Fit-for-purpose LC-MS/MS quantification of leukotoxin and leukotoxin diol in mouse plasma without sample pre-concentration.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1180: 122897, 2021 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-34450476
8.
Development of Orally Efficacious Allosteric Inhibitors of TNFα via Fragment-Based Drug Design.
J Med Chem
; 64(1): 417-429, 2021 01 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-33378180
9.
Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites.
Drug Metab Dispos
; 38(10): 1900-5, 2010 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-20595376
10.
Microphysiological systems for ADME-related applications: current status and recommendations for system development and characterization.
Lab Chip
; 20(3): 446-467, 2020 02 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31932816
11.
High throughput ADME screening: practical considerations, impact on the portfolio and enabler of in silico ADME models.
Curr Drug Metab
; 9(9): 847-53, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18991580
12.
Prodrugs for colon-restricted delivery: Design, synthesis, and in vivo evaluation of colony stimulating factor 1 receptor (CSF1R) inhibitors.
PLoS One
; 13(9): e0203567, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-30192846
13.
Navigating tissue chips from development to dissemination: A pharmaceutical industry perspective.
Exp Biol Med (Maywood)
; 242(16): 1579-1585, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28622731
14.
Optimized protein kinase Cθ (PKCθ) inhibitors reveal only modest anti-inflammatory efficacy in a rodent model of arthritis.
J Med Chem
; 58(1): 333-46, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25254961
15.
Discovery of selective and orally bioavailable protein kinase Cθ (PKCθ) inhibitors from a fragment hit.
J Med Chem
; 58(1): 222-36, 2015 Jan 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-25000588
16.
Discovery of (S)-6-(3-cyclopentyl-2-(4-(trifluoromethyl)-1H-imidazol-1-yl)propanamido)nicotinic acid as a hepatoselective glucokinase activator clinical candidate for treating type 2 diabetes mellitus.
J Med Chem
; 55(3): 1318-33, 2012 Feb 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-22196621
17.
Quantitative expression profile of hepatobiliary transporters in sandwich cultured rat and human hepatocytes.
Mol Pharm
; 6(4): 1180-9, 2009.
Artículo
en Inglés
| MEDLINE | ID: mdl-19545175
18.
Prediction of biliary excretion in rats and humans using molecular weight and quantitative structure-pharmacokinetic relationships.
AAPS J
; 11(3): 511-25, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19593675
19.
The development and validation of a computational model to predict rat liver microsomal clearance.
J Pharm Sci
; 98(8): 2857-67, 2009 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-19116953
20.
Role of hepatic transporters in the disposition and hepatotoxicity of a HER2 tyrosine kinase inhibitor CP-724,714.
Toxicol Sci
; 108(2): 492-500, 2009 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-19223659