Detalles de la búsqueda
1.
Rational design of balanced dual-targeting antibiotics with limited resistance.
PLoS Biol
; 18(10): e3000819, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-33017402
2.
Discovery of new ATP-competitive inhibitors of human DNA topoisomerase IIα through screening of bacterial topoisomerase inhibitors.
Bioorg Chem
; 102: 104049, 2020 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-32688116
3.
Discovery of Novel Hsp90 C-Terminal Inhibitors Using 3D-Pharmacophores Derived from Molecular Dynamics Simulations.
Int J Mol Sci
; 21(18)2020 Sep 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-32962253
4.
Estimation of passive gastrointestinal absorption of new dual DNA gyrase and topoisomerase IV inhibitors using PAMPA and biopartitioning micellar chromatography and quantitative structure-retention relationship analysis.
J Chromatogr B Analyt Technol Biomed Life Sci
; 1240: 124158, 2024 Jun 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38776787
5.
Benzothiazole DNA gyrase inhibitors and their conjugates with siderophore mimics: design, synthesis and evaluation.
RSC Adv
; 14(5): 2905-2917, 2024 Jan 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-38239435
6.
Estrogenic potency of endocrine disrupting chemicals and their mixtures detected in environmental waters and wastewaters.
Chemosphere
; 330: 138712, 2023 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-37068617
7.
New aryl and acylsulfonamides as state-dependent inhibitors of Nav1.3 voltage-gated sodium channel.
Eur J Med Chem
; 258: 115530, 2023 Oct 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-37329714
8.
ATP-competitive inhibitors of human DNA topoisomerase IIα with improved antiproliferative activity based on N-phenylpyrrolamide scaffold.
Eur J Med Chem
; 249: 115116, 2023 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36689894
9.
Exploring the 5-Substituted 2-Aminobenzothiazole-Based DNA Gyrase B Inhibitors Active against ESKAPE Pathogens.
ACS Omega
; 8(27): 24387-24395, 2023 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-37457471
10.
New Dual Inhibitors of Bacterial Topoisomerases with Broad-Spectrum Antibacterial Activity and In Vivo Efficacy against Vancomycin-Intermediate Staphylococcus aureus.
J Med Chem
; 66(6): 3968-3994, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36877255
11.
Discovery and Hit-to-Lead Optimization of Benzothiazole Scaffold-Based DNA Gyrase Inhibitors with Potent Activity against Acinetobacter baumannii and Pseudomonas aeruginosa.
J Med Chem
; 66(2): 1380-1425, 2023 01 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-36634346
12.
New bisphenol A and bisphenol S analogs: Evaluation of their hERα agonistic and antagonistic activities using the OECD 455 in-vitro assay and molecular modeling.
Chem Biol Interact
; 354: 109820, 2022 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35077665
13.
Last piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction.
Chemosphere
; 303(Pt 2): 135133, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35636595
14.
Structure-Activity Relationships of Benzothiazole-Based Hsp90 C-Terminal-Domain Inhibitors.
Pharmaceutics
; 13(8)2021 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-34452244
15.
Practical Synthesis and Application of Halogen-Doped Pyrrole Building Blocks.
ACS Omega
; 6(14): 9723-9730, 2021 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-33869952
16.
New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.
Eur J Med Chem
; 213: 113200, 2021 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-33524686
17.
Efficient Synthesis of Hydroxy-Substituted 2-Aminobenzo[d]thiazole-6-carboxylic Acid Derivatives as New Building Blocks in Drug Discovery.
ACS Omega
; 5(14): 8305-8311, 2020 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-32309742
18.
Hybrid Inhibitors of DNA Gyrase A and B: Design, Synthesis and Evaluation.
Pharmaceutics
; 13(1)2020 Dec 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-33374964
19.
ATP-competitive DNA gyrase and topoisomerase IV inhibitors as antibacterial agents.
Expert Opin Ther Pat
; 29(3): 171-180, 2019 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-30686070
20.
An optimised series of substituted N-phenylpyrrolamides as DNA gyrase B inhibitors.
Eur J Med Chem
; 167: 269-290, 2019 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30776691