Detalles de la búsqueda
1.
Enhancement of the Antitumor and Antimetastatic Effect of Topotecan and Normalization of Blood Counts in Mice with Lewis Carcinoma by Tdp1 Inhibitors-New Usnic Acid Derivatives.
Int J Mol Sci
; 25(2)2024 Jan 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38279210
2.
Mutant-Huntingtin Molecular Pathways Elucidate New Targets for Drug Repurposing.
Int J Mol Sci
; 24(23)2023 Nov 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-38069121
3.
Natural Products and Their Derivatives as Inhibitors of the DNA Repair Enzyme Tyrosyl-DNA Phosphodiesterase 1.
Int J Mol Sci
; 24(6)2023 Mar 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982848
4.
Novel TDP1 Inhibitors: Disubstituted Thiazolidine-2,4-Diones Containing Monoterpene Moieties.
Int J Mol Sci
; 24(4)2023 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36835244
5.
New 5-Hydroxycoumarin-Based Tyrosyl-DNA Phosphodiesterase I Inhibitors Sensitize Tumor Cell Line to Topotecan.
Int J Mol Sci
; 24(11)2023 May 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298106
6.
Transcriptomic Analysis of CRISPR/Cas9-Mediated PARP1-Knockout Cells under the Influence of Topotecan and TDP1 Inhibitor.
Int J Mol Sci
; 24(6)2023 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-36982223
7.
Monoterpene substituted thiazolidin-4-ones as novel TDP1 inhibitors: Synthesis, biological evaluation and docking.
Bioorg Med Chem Lett
; 73: 128909, 2022 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35907608
8.
Adamantane-Monoterpenoid Conjugates Linked via Heterocyclic Linkers Enhance the Cytotoxic Effect of Topotecan.
Molecules
; 27(11)2022 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35684313
9.
In Vitro and In Silico Studies of Human Tyrosyl-DNA Phosphodiesterase 1 (Tdp1) Inhibition by Stereoisomeric Forms of Lipophilic Nucleosides: The Role of Carbohydrate Stereochemistry in Ligand-Enzyme Interactions.
Molecules
; 27(8)2022 Apr 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-35458631
10.
The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Molecules
; 28(1)2022 Dec 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36615517
11.
DNA complexes with human apurinic/apyrimidinic endonuclease 1: structural insights revealed by pulsed dipolar EPR with orthogonal spin labeling.
Nucleic Acids Res
; 47(15): 7767-7780, 2019 09 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-31329919
12.
New Hybrid Compounds Combining Fragments of Usnic Acid and Thioether Are Inhibitors of Human Enzymes TDP1, TDP2 and PARP1.
Int J Mol Sci
; 22(21)2021 Oct 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-34768766
13.
New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2.
Molecules
; 27(1)2021 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-35011303
14.
Novel Tdp1 Inhibitors Based on Adamantane Connected with Monoterpene Moieties via Heterocyclic Fragments.
Molecules
; 26(11)2021 May 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-34073771
15.
Usnic Acid Conjugates with Monoterpenoids as Potent Tyrosyl-DNA Phosphodiesterase 1 Inhibitors.
J Nat Prod
; 83(8): 2320-2329, 2020 08 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32786885
16.
The First Berberine-Based Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), an Important DNA Repair Enzyme.
Int J Mol Sci
; 21(19)2020 Sep 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-32998385
17.
Inhibition of Tyrosyl-DNA Phosphodiesterase 1 by Lipophilic Pyrimidine Nucleosides.
Molecules
; 25(16)2020 Aug 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32823658
18.
Design, Synthesis, and Biological Investigation of Novel Classes of 3-Carene-Derived Potent Inhibitors of TDP1.
Molecules
; 25(15)2020 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-32751997
19.
Dual DNA topoisomerase 1 and tyrosyl-DNA phosphodiesterase 1 inhibition for improved anticancer activity.
Med Res Rev
; 39(4): 1427-1441, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31004352
20.
Dehydroabietylamine Ureas and Thioureas as Tyrosyl-DNA Phosphodiesterase 1 Inhibitors That Enhance the Antitumor Effect of Temozolomide on Glioblastoma Cells.
J Nat Prod
; 82(9): 2443-2450, 2019 09 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31430155