Detalles de la búsqueda
1.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37362320
2.
Discovery of new indole-based acylsulfonamide Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 29(4): 659-663, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30638874
3.
Discovery of morpholine-based aryl sulfonamides as Nav1.7 inhibitors.
Bioorg Med Chem Lett
; 28(5): 958-962, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29439904
4.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28818462
5.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
6.
The discovery of potent agonists for GPR88, an orphan GPCR, for the potential treatment of CNS disorders.
Bioorg Med Chem Lett
; 25(7): 1443-7, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754495
7.
Design, synthesis, and evaluation of phenylglycinols and phenyl amines as agonists of GPR88.
Bioorg Med Chem Lett
; 25(7): 1448-52, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25690789
8.
In vitro Characterization of a small molecule inhibitor of the alanine serine cysteine transporter -1 (SLC7A10).
J Neurochem
; 129(2): 275-83, 2014 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-24266811
9.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
ACS Med Chem Lett
; 15(4): 424-431, 2024 Apr 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38628790
10.
Empowering Voices: Inspiring Women in Medicinal Chemistry.
J Med Chem
; 67(6): 4251-4258, 2024 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-38456628
11.
Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
J Med Chem
; 66(6): 3651-3655, 2023 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-36884261
12.
Enhancing the Visibility of Women in the ACS Division of Medicinal Chemistry (ACS MEDI).
ACS Med Chem Lett
; 14(4): 345-349, 2023 Apr 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37077389
13.
Synthesis and structure-activity relationships of pyrido[3,2-b]pyrazin-3(4H)-ones and pteridin-7(8H)-ones as corticotropin-releasing factor-1 receptor antagonists.
Bioorg Med Chem Lett
; 22(15): 4986-9, 2012 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22749422
14.
Bicyclic Heterocyclic Replacement of an Aryl Amide Leading to Potent and Kinase-Selective Adaptor Protein 2-Associated Kinase 1 Inhibitors.
J Med Chem
; 65(5): 4121-4155, 2022 03 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35171586
15.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
16.
Discovery, Structure-Activity Relationships, and In Vivo Evaluation of Novel Aryl Amides as Brain Penetrant Adaptor Protein 2-Associated Kinase 1 (AAK1) Inhibitors for the Treatment of Neuropathic Pain.
J Med Chem
; 64(15): 11090-11128, 2021 08 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34270254
17.
Discovery of Indole- and Indazole-acylsulfonamides as Potent and Selective NaV1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 62(2): 831-856, 2019 01 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30576602
18.
Dihydropyridopyrazinones and dihydropteridinones as corticotropin-releasing factor-1 receptor antagonists: structure-activity relationships and computational modeling.
J Med Chem
; 50(9): 2269-72, 2007 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-17402721
19.
[3H]BMT-046091 a potent and selective radioligand to determine AAK1 distribution and target engagement.
Neuropharmacology
; 118: 167-174, 2017 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28315351
20.
Development of New Benzenesulfonamides As Potent and Selective Nav1.7 Inhibitors for the Treatment of Pain.
J Med Chem
; 60(6): 2513-2525, 2017 03 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-28234467