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1.
Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis.
J Neurosci
; 2024 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-38830764
2.
Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.
Neurobiol Dis
; 177: 105969, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36535551
3.
Discovery of pyrrolo[2,1-f][1,2,4]triazine-based inhibitors of adaptor protein 2-associated kinase 1 for the treatment of pain.
Med Chem Res
; : 1-7, 2023 Jun 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37362320
4.
Global proteomics of Ubqln2-based murine models of ALS.
J Biol Chem
; 296: 100153, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33277362
5.
Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aß42:Aß40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model.
J Neurosci
; 40(9): 1956-1974, 2020 02 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-31980586
6.
Genetic ablation of Gpnmb does not alter synuclein-related pathology.
Neurobiol Dis
; 159: 105494, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34464706
7.
Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS.
Neurobiol Dis
; 124: 340-352, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30528255
8.
Discovery of non-zwitterionic aryl sulfonamides as Nav1.7 inhibitors with efficacy in preclinical behavioral models and translational measures of nociceptive neuron activation.
Bioorg Med Chem
; 25(20): 5490-5505, 2017 10 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-28818462
9.
Triazolopyridine ethers as potent, orally active mGlu2 positive allosteric modulators for treating schizophrenia.
Bioorg Med Chem
; 25(2): 496-513, 2017 01 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27914948
10.
Inhibition of AAK1 Kinase as a Novel Therapeutic Approach to Treat Neuropathic Pain.
J Pharmacol Exp Ther
; 358(3): 371-86, 2016 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-27411717
11.
Oxazolidinone-based allosteric modulators of mGluR5: Defining molecular switches to create a pharmacological tool box.
Bioorg Med Chem Lett
; 26(17): 4165-9, 2016 09 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27496211
12.
Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential.
Bioorg Med Chem Lett
; 26(24): 5871-5876, 2016 12 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27856084
13.
Corrigendum to "Muscle specific kinase (MuSK) activation preserves neuromuscular junctions in the diaphragm but is not sufficient to provide a functional benefit in the SOD1G93A mouse model of ALS" Neurobiology of Disease 124 (2019) 340-352.
Neurobiol Dis
; 132: 104558, 2019 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-31471201
14.
A fluorescent splice-switching mouse model enables high-throughput, sensitive quantification of antisense oligonucleotide delivery and activity.
Cell Rep Methods
; 4(1): 100673, 2024 Jan 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-38171361
15.
Lipid nanoparticle delivery limits antisense oligonucleotide activity and cellular distribution in the brain after intracerebroventricular injection.
Mol Ther Nucleic Acids
; 32: 773-793, 2023 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-37346977
16.
TMEM106B reduction does not rescue GRN deficiency in iPSC-derived human microglia and mouse models.
iScience
; 26(11): 108362, 2023 Nov 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37965143
17.
Acute Neurotoxicity of Antisense Oligonucleotides After Intracerebroventricular Injection Into Mouse Brain Can Be Predicted from Sequence Features.
Nucleic Acid Ther
; 32(3): 151-162, 2022 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-35166597
18.
Identification and characterization of a MAPT-targeting locked nucleic acid antisense oligonucleotide therapeutic for tauopathies.
Mol Ther Nucleic Acids
; 29: 625-642, 2022 Sep 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-36090761
19.
Discovery and Optimization of Biaryl Alkyl Ethers as a Novel Class of Highly Selective, CNS-Penetrable, and Orally Active Adaptor Protein-2-Associated Kinase 1 (AAK1) Inhibitors for the Potential Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4534-4564, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35261239
20.
Discovery of (S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain.
J Med Chem
; 65(6): 4457-4480, 2022 03 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-35257579