Detalles de la búsqueda
1.
The Dopamine D1 Receptor Positive Allosteric Modulator Mevidalen (LY3154207) Enhances Wakefulness in the Humanized D1 Mouse and in Sleep-Deprived Healthy Male Volunteers.
J Pharmacol Exp Ther
; 380(3): 143-152, 2022 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-34893551
2.
Quantitative propagation of assembled human Tau from Alzheimer's disease brain in microfluidic neuronal cultures.
J Biol Chem
; 295(37): 13079-13093, 2020 09 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32699110
3.
Mechanism of action deconvolution of the small-molecule pathological tau aggregation inhibitor Anle138b.
Alzheimers Res Ther
; 15(1): 52, 2023 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-36918909
4.
A human tau seeded neuronal cell model recapitulates molecular responses associated with Alzheimer's disease.
Sci Rep
; 12(1): 2673, 2022 02 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-35177665
5.
Development of an Electrophysiological Assay for Kv7 Modulators on IonWorks Barracuda.
Assay Drug Dev Technol
; 17(7): 310-321, 2019 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-31634018
6.
Pharmacological Modulation of Sleep Homeostasis in Rat: Novel Effects of an mGluR2/3 Antagonist.
Sleep
; 42(9)2019 09 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-31106825
7.
A Bayesian gene network reveals insight into the JAK-STAT pathway in systemic lupus erythematosus.
PLoS One
; 14(12): e0225651, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31790472
8.
Expression-based drug screening of neural progenitor cells from individuals with schizophrenia.
Nat Commun
; 9(1): 4412, 2018 10 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-30356048
9.
Author Correction: Expression-based drug screening of neural progenitor cells from individuals with schizophrenia.
Nat Commun
; 9(1): 4926, 2018 11 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-30451900
10.
Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model.
Mol Neurodegener
; 13(1): 65, 2018 12 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-30558641
11.
Preclinical profile of a dopamine D1 potentiator suggests therapeutic utility in neurological and psychiatric disorders.
Neuropharmacology
; 128: 351-365, 2018 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-29102759
12.
Electroencephalographic, cognitive, and neurochemical effects of LY3130481 (CERC-611), a selective antagonist of TARP-γ8-associated AMPA receptors.
Neuropharmacology
; 126: 257-270, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28757050
13.
Analgesic effects of serotonergic, noradrenergic or dual reuptake inhibitors in the carrageenan test in rats: evidence for synergism between serotonergic and noradrenergic reuptake inhibition.
Neuropharmacology
; 51(7-8): 1172-80, 2006 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-17045620
14.
A comparison of assay performance measures in screening assays: signal window, Z' factor, and assay variability ratio.
J Biomol Screen
; 11(3): 247-52, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16490779
15.
The minimum significant ratio: a statistical parameter to characterize the reproducibility of potency estimates from concentration-response assays and estimation by replicate-experiment studies.
J Biomol Screen
; 11(3): 253-61, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16490778
16.
Advances in the genetics of schizophrenia: toward a network and pathway view for drug discovery.
Ann N Y Acad Sci
; 1366(1): 61-75, 2016 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27111133
17.
Myostatin Neutralization Results in Preservation of Muscle Mass and Strength in Preclinical Models of Tumor-Induced Muscle Wasting.
Mol Cancer Ther
; 14(7): 1661-70, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25908685
18.
Activation of mesolimbic dopamine neurons during novel and daily limited access to palatable food is blocked by the opioid antagonist LY255582.
Am J Physiol Regul Integr Comp Physiol
; 295(2): R463-71, 2008 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-18525013
19.
Dopamine D1/5 receptor modulation of firing rate and bidirectional theta burst firing in medial septal/vertical limb of diagonal band neurons in vivo.
J Neurophysiol
; 95(5): 2808-20, 2006 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-16452256
20.
Effect of sampling frames on response rates in the WHO MONICA risk factor surveys.
Eur J Epidemiol
; 20(4): 293-9, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-15971500