Detalles de la búsqueda
1.
Analogs of α-conotoxin PnIC selectively inhibit α7ß2- over α7-only subtype nicotinic acetylcholine receptors via a novel allosteric mechanism.
FASEB J
; 38(1): e23374, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38161283
2.
Differential α4(+)/(-)ß2 Agonist-binding Site Contributions to α4ß2 Nicotinic Acetylcholine Receptor Function within and between Isoforms.
J Biol Chem
; 291(5): 2444-59, 2016 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-26644472
3.
The unique α4+/-α4 agonist binding site in (α4)3(ß2)2 subtype nicotinic acetylcholine receptors permits differential agonist desensitization pharmacology versus the (α4)2(ß2)3 subtype.
J Pharmacol Exp Ther
; 348(1): 46-58, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24190916
4.
High-throughput cell-based assays for identifying antagonists of multiple smoking-associated human nicotinic acetylcholine receptor subtypes.
SLAS Discov
; 27(1): 68-76, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-35058178
5.
α1-FANGs: Protein Ligands Selective for the α-Bungarotoxin Site of the α1-Nicotinic Acetylcholine Receptor.
ACS Chem Biol
; 13(9): 2568-2576, 2018 09 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30059207
6.
Synthesis and Behavioral Studies of Chiral Cyclopropanes as Selective α4ß2-Nicotinic Acetylcholine Receptor Partial Agonists Exhibiting an Antidepressant Profile. Part III.
ACS Chem Neurosci
; 7(6): 811-22, 2016 06 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27035276
7.
Synthesis and biological evaluation of novel hybrids of highly potent and selective α4ß2-Nicotinic acetylcholine receptor (nAChR) partial agonists.
Eur J Med Chem
; 124: 689-697, 2016 Nov 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-27639361
8.
Enantiopure Cyclopropane-Bearing Pyridyldiazabicyclo[3.3.0]octanes as Selective α4ß2-nAChR Ligands.
ACS Med Chem Lett
; 5(11): 1196-201, 2014 Nov 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25408831
9.
Recent developments in novel antidepressants targeting α4ß2-nicotinic acetylcholine receptors.
J Med Chem
; 57(20): 8204-23, 2014 Oct 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-24901260
10.
Chemistry, pharmacology, and behavioral studies identify chiral cyclopropanes as selective α4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile. Part II.
J Med Chem
; 56(13): 5495-504, 2013 Jul 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-23734673
11.
Discovery of highly potent and selective α4ß2-nicotinic acetylcholine receptor (nAChR) partial agonists containing an isoxazolylpyridine ether scaffold that demonstrate antidepressant-like activity. Part II.
J Med Chem
; 55(22): 9998-10009, 2012 Nov 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-23092294
12.
Identification of novel α4ß2-nicotinic acetylcholine receptor (nAChR) agonists based on an isoxazole ether scaffold that demonstrate antidepressant-like activity.
J Med Chem
; 55(2): 812-23, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22148173
13.
Chemistry and behavioral studies identify chiral cyclopropanes as selective α4ß2-nicotinic acetylcholine receptor partial agonists exhibiting an antidepressant profile.
J Med Chem
; 55(2): 717-24, 2012 Jan 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-22171543
14.
Insights into the structural determinants required for high-affinity binding of chiral cyclopropane-containing ligands to α4ß2-nicotinic acetylcholine receptors: an integrated approach to behaviorally active nicotinic ligands.
J Med Chem
; 55(18): 8028-37, 2012 Sep 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-22928944
15.
Synthesis of 2-(substituted phenyl)-3,5,5-trimethylmorpholine analogues and their effects on monoamine uptake, nicotinic acetylcholine receptor function, and behavioral effects of nicotine.
J Med Chem
; 54(5): 1441-8, 2011 Mar 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-21319801
16.
Discovery of isoxazole analogues of sazetidine-A as selective α4ß2-nicotinic acetylcholine receptor partial agonists for the treatment of depression.
J Med Chem
; 54(20): 7280-8, 2011 Oct 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-21905669
17.
Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4ß2-nicotinic acetylcholine receptor-selective partial agonists.
J Med Chem
; 53(19): 6973-85, 2010 Oct 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-20822184
18.
Nicotinic acetylcholine receptor efficacy and pharmacological properties of 3-(substituted phenyl)-2ß-substituted tropanes.
J Med Chem
; 53(23): 8345-53, 2010 Dec 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21058665
19.
Synthesis and biological evaluation of bupropion analogues as potential pharmacotherapies for smoking cessation.
J Med Chem
; 53(5): 2204-14, 2010 Mar 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-20158204
20.
Synthesis and characterization of in vitro and in vivo profiles of hydroxybupropion analogues: aids to smoking cessation.
J Med Chem
; 53(12): 4731-48, 2010 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-20509659