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1.
Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1.
Bioorg Med Chem
; 28(10): 115481, 2020 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-32253095
2.
Discovery of Clinical Candidate PF-06648671: A Potent γ-Secretase Modulator for the Treatment of Alzheimer's Disease.
J Med Chem
; 2024 Jun 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-38848667
3.
Dual Inhibition of TYK2 and JAK1 for the Treatment of Autoimmune Diseases: Discovery of (( S)-2,2-Difluorocyclopropyl)((1 R,5 S)-3-(2-((1-methyl-1 H-pyrazol-4-yl)amino)pyrimidin-4-yl)-3,8-diazabicyclo[3.2.1]octan-8-yl)methanone (PF-06700841).
J Med Chem
; 61(19): 8597-8612, 2018 10 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-30113844
4.
Binding screen for cystic fibrosis transmembrane conductance regulator correctors finds new chemical matter and yields insights into cystic fibrosis therapeutic strategy.
Protein Sci
; 25(2): 360-73, 2016 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26444971
5.
Discovery and optimization of a novel spiropyrrolidine inhibitor of ß-secretase (BACE1) through fragment-based drug design.
J Med Chem
; 55(21): 9069-88, 2012 Nov 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22468999
6.
Application of the bicyclo[1.1.1]pentane motif as a nonclassical phenyl ring bioisostere in the design of a potent and orally active γ-secretase inhibitor.
J Med Chem
; 55(7): 3414-24, 2012 Apr 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-22420884
7.
1-[(1-methyl-1H-imidazol-2-yl)methyl]-4-phenylpiperidines as mGluR2 positive allosteric modulators for the treatment of psychosis.
J Med Chem
; 54(6): 1724-39, 2011 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21366332
8.
Metabolism-directed design of oxetane-containing arylsulfonamide derivatives as γ-secretase inhibitors.
J Med Chem
; 54(22): 7772-83, 2011 Nov 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-21995460
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