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1.
Exploring the Potential of RET Kinase Inhibition for Irritable Bowel Syndrome: A Preclinical Investigation in Rodent Models of Colonic Hypersensitivity.
J Pharmacol Exp Ther
; 368(2): 299-307, 2019 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-30413627
2.
TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury.
Am J Physiol Lung Cell Mol Physiol
; 307(2): L158-72, 2014 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-24838754
3.
Enteric RET inhibition attenuates gastrointestinal secretion and motility via cholinergic signaling in rat colonic mucosal preparations.
Neurogastroenterol Motil
; 31(4): e13479, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30311722
4.
Discovery of GSK2798745: A Clinical Candidate for Inhibition of Transient Receptor Potential Vanilloid 4 (TRPV4).
ACS Med Chem Lett
; 10(8): 1228-1233, 2019 Aug 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31413810
5.
Discovery of GSK2193874: An Orally Active, Potent, and Selective Blocker of Transient Receptor Potential Vanilloid 4.
ACS Med Chem Lett
; 8(5): 549-554, 2017 May 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-28523109
6.
Palladium- and copper-catalyzed 1,4-additions of organozinc compounds to conjugated aldehydes.
Org Lett
; 8(24): 5505-8, 2006 Nov 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-17107058
7.
Optimization of a Novel Series of TRPV4 Antagonists with In Vivo Activity in a Model of Pulmonary Edema.
ACS Med Chem Lett
; 4(2): 293-6, 2013 Feb 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24900661
8.
An orally active TRPV4 channel blocker prevents and resolves pulmonary edema induced by heart failure.
Sci Transl Med
; 4(159): 159ra148, 2012 Nov 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-23136043
9.
Hydroxyamide analogs of propofol exhibit state-dependent block of sodium channels in hippocampal neurons: implications for anticonvulsant activity.
J Pharmacol Exp Ther
; 320(2): 828-36, 2007 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17090703
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