Detalles de la búsqueda
1.
MATE1 Deficiency Exacerbates Dofetilide-Induced Proarrhythmia.
Int J Mol Sci
; 23(15)2022 Aug 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-35955741
2.
Evaluation of the Absorption, Metabolism, and Excretion of a Single Oral 1-mg Dose of Tropifexor in Healthy Male Subjects and the Concentration Dependence of Tropifexor Metabolism.
Drug Metab Dispos
; 49(7): 548-562, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33952610
3.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro Cytochrome P450 Induction Studies Including Impact on Drug Interaction Risk Assessment.
Drug Metab Dispos
; 49(1): 94-110, 2021 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33139460
4.
Disposition of asciminib, a potent BCR-ABL1 tyrosine kinase inhibitor, in healthy male subjects.
Xenobiotica
; 50(2): 150-169, 2020 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-31006307
5.
Evaluation of Clinical Drug Interaction Potential of Clofazimine Using Static and Dynamic Modeling Approaches.
Drug Metab Dispos
; 46(1): 26-32, 2018 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29038231
6.
Simultaneous Physiologically Based Pharmacokinetic (PBPK) Modeling of Parent and Active Metabolites to Investigate Complex CYP3A4 Drug-Drug Interaction Potential: A Case Example of Midostaurin.
Drug Metab Dispos
; 46(2): 109-121, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-29117990
7.
Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidances from Regulatory Agencies: Focus on CYP3A4 mRNA In Vitro Response Thresholds, Variability, and Clinical Relevance.
Drug Metab Dispos
; 46(9): 1285-1303, 2018 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-29959133
8.
A Physiologically-Based Pharmacokinetic Modeling Approach To Predict Drug-Drug Interactions of Sonidegib (LDE225) with Perpetrators of CYP3A in Cancer Patients.
Drug Metab Dispos
; 45(4): 361-374, 2017 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-28122787
9.
Physiologically Based Pharmacokinetic Model Predictions of Panobinostat (LBH589) as a Victim and Perpetrator of Drug-Drug Interactions.
Drug Metab Dispos
; 45(12): 1304-1316, 2017 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28912253
10.
Considerations from the IQ Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Focus on Downregulation, CYP2C Induction, and CYP2B6 Positive Control.
Drug Metab Dispos
; 45(10): 1049-1059, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28646080
11.
Pradigastat disposition in humans: in vivo and in vitro investigations.
Xenobiotica
; 47(12): 1077-1089, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27855567
12.
Clinical disposition, metabolism and in vitro drug-drug interaction properties of omadacycline.
Xenobiotica
; 47(8): 682-696, 2017 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-27499331
13.
Evaluation of CYP2B6 Induction and Prediction of Clinical Drug-Drug Interactions: Considerations from the IQ Consortium Induction Working Group-An Industry Perspective.
Drug Metab Dispos
; 44(10): 1720-30, 2016 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-27422672
14.
Identification of Three Novel Ring Expansion Metabolites of KAE609, a New Spiroindolone Agent for the Treatment of Malaria, in Rats, Dogs, and Humans.
Drug Metab Dispos
; 44(5): 653-64, 2016 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-26921386
15.
Evaluation of a New Molecular Entity as a Victim of Metabolic Drug-Drug Interactions-an Industry Perspective.
Drug Metab Dispos
; 44(8): 1399-423, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27052879
16.
Disposition and metabolism of [(14)C] Sacubitril/Valsartan (formerly LCZ696) an angiotensin receptor neprilysin inhibitor, in healthy subjects.
Xenobiotica
; 46(11): 986-1000, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26931777
17.
Evaluation of calibration curve-based approaches to predict clinical inducers and noninducers of CYP3A4 with plated human hepatocytes.
Drug Metab Dispos
; 42(9): 1379-91, 2014 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-24924386
18.
Cytochrome P450 1A2 detoxicates aristolochic acid in the mouse.
Drug Metab Dispos
; 38(5): 761-8, 2010 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-20164109
19.
Model-Informed Drug Development for Everolimus Dosing Selection in Pediatric Infant Patients.
CPT Pharmacometrics Syst Pharmacol
; 9(4): 230-237, 2020 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-32150661
20.
Absorption, metabolism, and excretion of [14C]vildagliptin, a novel dipeptidyl peptidase 4 inhibitor, in humans.
Drug Metab Dispos
; 37(3): 536-44, 2009 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-19074975