Detalles de la búsqueda
1.
Development of a highly sensitive liquid chromatography-mass spectrometry method to quantify plasma leukotriene E4 and demonstrate pharmacological suppression of endogenous 5-LO pathway activity in man.
Prostaglandins Other Lipid Mediat
; 150: 106463, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32450304
2.
Cytokine Profiles in Autoantibody Defined Subgroups of Systemic Lupus Erythematosus.
J Proteome Res
; 18(3): 1208-1217, 2019 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30742448
3.
Microparticles in the blood of patients with SLE: Size, content of mitochondria and role in circulating immune complexes.
J Autoimmun
; 102: 142-149, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31103269
4.
Novel gene variants associated with cardiovascular disease in systemic lupus erythematosus and rheumatoid arthritis.
Ann Rheum Dis
; 77(7): 1063-1069, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29514802
5.
Revisiting the peripheral sink hypothesis: inhibiting BACE1 activity in the periphery does not alter ß-amyloid levels in the CNS.
J Neurochem
; 132(4): 477-86, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25156639
6.
AZ-4217: a high potency BACE inhibitor displaying acute central efficacy in different in vivo models and reduced amyloid deposition in Tg2576 mice.
J Neurosci
; 33(24): 10075-84, 2013 Jun 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23761903
7.
Population PKPD modeling of BACE1 inhibitor-induced reduction in Aß levels in vivo and correlation to in vitro potency in primary cortical neurons from mouse and guinea pig.
Pharm Res
; 31(3): 670-83, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24092053
8.
Discovery of AZD3839, a potent and selective BACE1 inhibitor clinical candidate for the treatment of Alzheimer disease.
J Biol Chem
; 287(49): 41245-57, 2012 Nov 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-23048024
9.
Vascular endothelial growth factor-D plasma levels and VEGFD genetic variants are independently associated with outcomes in patients with cardiovascular disease.
Cardiovasc Res
; 119(7): 1596-1605, 2023 07 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36869765
10.
Four Systemic Lupus Erythematosus Subgroups, Defined by Autoantibodies Status, Differ Regarding HLA-DRB1 Genotype Associations and Immunological and Clinical Manifestations.
ACR Open Rheumatol
; 4(1): 27-39, 2022 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-34658170
11.
Sjögren Syndrome in Systemic Lupus Erythematosus: A Subset Characterized by a Systemic Inflammatory State.
J Rheumatol
; 47(6): 865-875, 2020 06 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31523050
12.
Highly sensitive and specific LC-MS/MS method to determine endogenous leukotriene B4 levels in human plasma.
Bioanalysis
; 11(11): 1055-1066, 2019 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-31251101
13.
High levels of circulating interferons type I, type II and type III associate with distinct clinical features of active systemic lupus erythematosus.
Arthritis Res Ther
; 21(1): 107, 2019 04 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-31036046
14.
TNF-α and plasma albumin as biomarkers of disease activity in systemic lupus erythematosus.
Lupus Sci Med
; 5(1): e000260, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29955370
15.
Kynurenine pathway is altered in patients with SLE and associated with severe fatigue.
Lupus Sci Med
; 5(1): e000254, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29868176
16.
Toward ß-Secretase-1 Inhibitors with Improved Isoform Selectivity.
J Med Chem
; 61(8): 3491-3502, 2018 04 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-29617572
17.
Determining myeloperoxidase activity and protein concentration in a single assay: Utility in biomarker and therapeutic studies.
J Immunol Methods
; 449: 76-79, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28713008
18.
BACE1 Inhibitor Lanabecestat (AZD3293) in a Phase 1 Study of Healthy Japanese Subjects: Pharmacokinetics and Effects on Plasma and Cerebrospinal Fluid Aß Peptides.
J Clin Pharmacol
; 57(11): 1460-1471, 2017 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-28618005
19.
AZD3293: Pharmacokinetic and Pharmacodynamic Effects in Healthy Subjects and Patients with Alzheimer's Disease.
J Alzheimers Dis
; 55(3): 1039-1053, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27767991
20.
TREM2 shedding by cleavage at the H157-S158 bond is accelerated for the Alzheimer's disease-associated H157Y variant.
EMBO Mol Med
; 9(10): 1366-1378, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28855301