Detalles de la búsqueda
1.
Synthesis, molecular modeling simulations and anticancer activity of some new Imidazo[2,1-b]thiazole analogues as EGFR/HER2 and DHFR inhibitors.
Bioorg Chem
; 150: 107538, 2024 Jun 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-38861913
2.
Hydrazinecarbonyl-thiazol-2-acetamides with pronounced apoptotic behavior: synthesis, in vitro/in vivo anti-proliferative activity and molecular modeling simulations.
Bioorg Med Chem Lett
; 87: 129285, 2023 05 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37054758
3.
New quinazolinone-based derivatives as DHFR/EGFR-TK inhibitors: Synthesis, molecular modeling simulations, and anticancer activity.
Arch Pharm (Weinheim)
; 356(1): e2200417, 2023 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-36257809
4.
New phthalimide-based derivatives as EGFR-TK inhibitors: Synthesis, biological evaluation, and molecular modeling study.
Bioorg Chem
; 127: 105966, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-35728294
5.
Thiazole-based SARS-CoV-2 protease (COV Mpro ) inhibitors: Design, synthesis, enzyme inhibition, and molecular modeling simulations.
Arch Pharm (Weinheim)
; 355(9): e2200121, 2022 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-35607750
6.
Novel 1,2,4-oxadiazole-chalcone/oxime hybrids as potential antibacterial DNA gyrase inhibitors: Design, synthesis, ADMET prediction and molecular docking study.
Bioorg Chem
; 111: 104885, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33838559
7.
3-Methyl-imidazo[2,1-b]thiazole derivatives as a new class of antifolates: Synthesis, in vitro/in vivo bio-evaluation and molecular modeling simulations.
Bioorg Chem
; 115: 105205, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34329992
8.
Nanomolar potency of imidazo[2,1-b]thiazole analogs as indoleamine 2,3-dioxygenase inhibitors.
Arch Pharm (Weinheim)
; 354(11): e2100202, 2021 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-34313342
9.
Design, synthesis and molecular modeling of novel aryl carboximidamides and 3-aryl-1,2,4-oxadiazoles derived from indomethacin as potent anti-inflammatory iNOS/PGE2 inhibitors.
Bioorg Chem
; 105: 104439, 2020 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-33161252
10.
Synthesis, antitumor testing and molecular modeling study of some new 6-substituted amido, azo or thioureido-quinazolin-4(3H)-ones.
Bioorg Chem
; 88: 102923, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-30991189
11.
Imidazo[2',1':2,3]thiazolo[4,5-d]pyridazinone as a new scaffold of DHFR inhibitors: Synthesis, biological evaluation and molecular modeling study.
Bioorg Chem
; 80: 11-23, 2018 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-29864684
12.
Thiazolo[4,5-d]pyridazine analogues as a new class of dihydrofolate reductase (DHFR) inhibitors: Synthesis, biological evaluation and molecular modeling study.
Bioorg Chem
; 74: 228-237, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28865294
13.
Synthesis, biological evaluation and molecular modeling study of new (1,2,4-triazole or 1,3,4-thiadiazole)-methylthio-derivatives of quinazolin-4(3H)-one as DHFR inhibitors.
Bioorg Chem
; 72: 282-292, 2017 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28499189
14.
Synthesis, biological evaluation and molecular modeling study of some new methoxylated 2-benzylthio-quinazoline-4(3H)-ones as nonclassical antifolates.
Bioorg Med Chem Lett
; 26(19): 4815-4823, 2016 10 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27554444
15.
Synthesis, biological evaluation and molecular modeling study of some new thiazolodiazepine analogs as CNS active agents.
Bioorg Med Chem Lett
; 26(2): 445-453, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26706170
16.
Synthesis, anticonvulsant activity and molecular modeling study of some new hydrazinecarbothioamide, benzenesulfonohydrazide, and phenacylacetohydrazide analogues of 4(3H)-quinazolinone.
Bioorg Med Chem Lett
; 25(7): 1490-9, 2015 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25754489
17.
Synthesis, biological evaluation and molecular modeling study of 2-(1,3,4-thiadiazolyl-thio and 4-methyl-thiazolyl-thio)-quinazolin-4-ones as a new class of DHFR inhibitors.
Bioorg Med Chem Lett
; 24(18): 4557-4567, 2014 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25139568
18.
Multi-targeted anti-Alzheimer's agents: Synthesis, biological evaluation, and molecular modeling study of some pyrazolopyridine hybrids.
Eur J Med Chem
; 262: 115880, 2023 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37871406
19.
Discovery of new pyridine heterocyclic hybrids; design, synthesis, dynamic simulations, and in vitro and in vivo breast cancer biological assays.
RSC Adv
; 13(23): 15689-15703, 2023 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-37235111
20.
Substituted thiazoles VII. Synthesis and antitumor activity of certain 2-(substituted amino)-4-phenyl-1,3-thiazole analogs.
Bioorg Med Chem Lett
; 22(20): 6318-23, 2012 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22995621