Detalles de la búsqueda
1.
Synthesis, pharmacological evaluation, DFT calculation, and theoretical investigation of spirocyclohexane derivatives.
Bioorg Chem
; 131: 106280, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36436418
2.
Design and synthesis of uracil/thiouracil based quinoline scaffolds as topoisomerases I/II inhibitors for chemotherapy: A new hybrid navigator with DFT calculation.
Bioorg Chem
; 136: 106560, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37121108
3.
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
J Enzyme Inhib Med Chem
; 38(1): 2242714, 2023 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37592917
4.
Synthesis, DFT calculations, and anti-proliferative evaluation of pyrimidine and selenadiazolopyrimidine derivatives as dual Topoisomerase II and HSP90 inhibitors.
J Enzyme Inhib Med Chem
; 38(1): 2198163, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37036011
5.
Novel pyrimidine Schiff bases and their selenium-containing nanoparticles as dual inhibitors of CDK1 and tubulin polymerase: design, synthesis, anti-proliferative evaluation, and molecular modelling.
J Enzyme Inhib Med Chem
; 38(1): 2232125, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37403517
6.
Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs.
Int J Mol Sci
; 24(15)2023 Aug 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37569792
7.
In vitro antimicrobial evaluation and in silico studies of coumarin derivatives tagged with pyrano-pyridine and pyrano-pyrimidine moieties as DNA gyrase inhibitors.
Mol Divers
; 26(1): 341-363, 2022 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-33895960
8.
Synthesis, In Silico Prediction and In Vitro Evaluation of Antimicrobial Activity, DFT Calculation and Theoretical Investigation of Novel Xanthines and Uracil Containing Imidazolone Derivatives.
Int J Mol Sci
; 22(20)2021 Oct 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34681643
9.
Synthesis, In Silico Prediction and In Vitro Evaluation of Antitumor Activities of Novel Pyrido[2,3-d]pyrimidine, Xanthine and Lumazine Derivatives.
Molecules
; 25(21)2020 Nov 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-33182318
10.
Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity.
Molecules
; 23(7)2018 Jun 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-29966318
11.
A Novel Synthesis of Fused Uracils: Indenopyrimidopyridazines, Pyrimidopyridazines, and Pyrazolopyrimidines for Antimicrobial and Antitumor Evalution.
Molecules
; 21(12)2016 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27983644
12.
Novel 2-Thioxanthine and Dipyrimidopyridine Derivatives: Synthesis and Antimicrobial Activity.
Molecules
; 20(10): 19263-76, 2015 Oct 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-26506337
13.
Synthesis and in vitro study of pyrimidine-phthalimide hybrids as VEGFR2 inhibitors with antiproliferative activity.
Future Med Chem
; 15(8): 661-677, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-37125606
14.
Design, Synthesis, and Anti-Proliferative Action of Purine/Pteridine-Based Derivatives as Dual Inhibitors of EGFR and BRAFV600E.
Pharmaceuticals (Basel)
; 16(5)2023 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242499
15.
Design, synthesis and antitumor activity of novel pyran-functionalized uracil derivatives: docking studies.
Future Med Chem
; 15(5): 421-436, 2023 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-37009754
16.
Novel Aminopyrimidine-2,4-diones, 2-Thiopyrimidine-4-ones, and 6-Arylpteridines as Dual-Target Inhibitors of BRD4/PLK1: Design, Synthesis, Cytotoxicity, and Computational Studies.
Pharmaceuticals (Basel)
; 16(9)2023 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-37765111
17.
Discovery of New Uracil and Thiouracil Derivatives as Potential HDAC Inhibitors.
Pharmaceuticals (Basel)
; 16(7)2023 Jul 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37513878
18.
New thiouracil derivatives as histone deacetylase inhibitors and apoptosis inducers: design, synthesis and anticancer evaluation.
Future Med Chem
; 15(12): 1019-1035, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37492951
19.
Design and synthesis of novel uracil-linked Schiff bases as dual histone deacetylase type II/topoisomerase type I inhibitors with apoptotic potential.
Future Med Chem
; 15(11): 937-958, 2023 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-37381751
20.
Uracil as a Zn-Binding Bioisostere of the Allergic Benzenesulfonamide in the Design of Quinoline-Uracil Hybrids as Anticancer Carbonic Anhydrase Inhibitors.
Pharmaceuticals (Basel)
; 15(5)2022 Apr 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-35631321