Detalles de la búsqueda
1.
Rational design, synthesis, biological evaluation, and molecular modeling of novel naphthamide derivatives possessing potent, reversible, and competitive inhibitory mode of action over human monoamine oxidase.
Mol Divers
; 2024 May 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-38727994
2.
Design and synthesis of new spirooxindole candidates and their selenium nanoparticles as potential dual Topo I/II inhibitors, DNA intercalators, and apoptotic inducers.
J Enzyme Inhib Med Chem
; 38(1): 2242714, 2023 Aug 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-37592917
3.
Novel topoisomerase II/EGFR dual inhibitors: design, synthesis and docking studies of naphtho[2',3':4,5]thiazolo[3,2-a]pyrimidine hybrids as potential anticancer agents with apoptosis inducing activity.
J Enzyme Inhib Med Chem
; 38(1): 2205043, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37165800
4.
Investigating the potential anticancer activities of antibiotics as topoisomerase II inhibitors and DNA intercalators: in vitro, molecular docking, molecular dynamics, and SAR studies.
J Enzyme Inhib Med Chem
; 38(1): 2171029, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-36701269
5.
Development of new TAK-285 derivatives as potent EGFR/HER2 inhibitors possessing antiproliferative effects against 22RV1 and PC3 prostate carcinoma cell lines.
J Enzyme Inhib Med Chem
; 38(1): 2202358, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37096560
6.
Small Molecule c-KIT Inhibitors for the Treatment of Gastrointestinal Stromal Tumors: A Review on Synthesis, Design Strategies, and Structure-Activity Relationship (SAR).
Int J Mol Sci
; 24(11)2023 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-37298401
7.
Therapeutic potential of natural products in inflammation: underlying molecular mechanisms, clinical outcomes, technological advances, and future perspectives.
Inflammopharmacology
; 31(6): 2857-2883, 2023 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-37950803
8.
4-Anilinoquinazoline-based benzenesulfonamides as nanomolar inhibitors of carbonic anhydrase isoforms I, II, IX, and XII: design, synthesis, in-vitro, and in-silico biological studies.
J Enzyme Inhib Med Chem
; 37(1): 994-1004, 2022 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-35350942
9.
Identification of Novel and Potent Indole-Based Benzenesulfonamides as Selective Human Carbonic Anhydrase II Inhibitors: Design, Synthesis, In Vitro, and In Silico Studies.
Int J Mol Sci
; 23(5)2022 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-35269684
10.
Suppression of Tumor Growth and Cell Migration by Indole-Based Benzenesulfonamides and Their Synergistic Effects in Combination with Doxorubicin.
Int J Mol Sci
; 23(17)2022 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36077298
11.
Discovery of novel and potent safinamide-based derivatives as highly selective hMAO-B inhibitors for treatment of Parkinson's disease (PD): Design, synthesis, in vitro, in vivo and in silico biological studies.
Bioorg Chem
; 115: 105233, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34390968
12.
Discovery of 3,4-dichloro-N-(1H-indol-5-yl)benzamide: A highly potent, selective, and competitive hMAO-B inhibitor with high BBB permeability profile and neuroprotective action.
Bioorg Chem
; 116: 105352, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34562673
13.
New horizons in drug discovery of lymphocyte-specific protein tyrosine kinase (Lck) inhibitors: a decade review (2011-2021) focussing on structure-activity relationship (SAR) and docking insights.
J Enzyme Inhib Med Chem
; 36(1): 1574-1602, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34233563
14.
The Journey of DDR1 and DDR2 Kinase Inhibitors as Rising Stars in the Fight Against Cancer.
Int J Mol Sci
; 22(12)2021 Jun 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-34207360
15.
Structure Activity Relationship of Key Heterocyclic Anti-Angiogenic Leads of Promising Potential in the Fight against Cancer.
Molecules
; 26(3)2021 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-33494492
16.
Scaffold Repurposing of In-House Small Molecule Candidates Leads to Discovery of First-in-Class CDK-1/HER-2 Dual Inhibitors: In Vitro and In Silico Screening.
Molecules
; 26(17)2021 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34500757
17.
Sulfonamide-based 4-anilinoquinoline derivatives as novel dual Aurora kinase (AURKA/B) inhibitors: Synthesis, biological evaluation and in silico insights.
Bioorg Med Chem
; 28(13): 115525, 2020 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32371117
18.
Discovery of N-(1-(3-fluorobenzoyl)-1H-indol-5-yl)pyrazine-2-carboxamide: a novel, selective, and competitive indole-based lead inhibitor for human monoamine oxidase B.
J Enzyme Inhib Med Chem
; 35(1): 1568-1580, 2020 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-32752896
19.
EGFR inhibitors from cancer to inflammation: Discovery of 4-fluoro-N-(4-(3-(trifluoromethyl)phenoxy)pyrimidin-5-yl)benzamide as a novel anti-inflammatory EGFR inhibitor.
Bioorg Chem
; 86: 112-118, 2019 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-30685642
20.
Optimization study towards more potent thiazolidine-2,4-dione IKK-ß modulator: Synthesis, biological evaluation and in silico docking simulation.
Bioorg Chem
; 92: 103261, 2019 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-31542718