Detalles de la búsqueda
1.
Proteomic Analysis of Huntington's Disease Medium Spiny Neurons Identifies Alterations in Lipid Droplets.
Mol Cell Proteomics
; 22(5): 100534, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36958627
2.
Proteomic analysis of X-linked dystonia parkinsonism disease striatal neurons reveals altered RNA metabolism and splicing.
Neurobiol Dis
; 190: 106367, 2024 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-38042508
3.
TYROBP/DAP12 knockout in Huntington's disease Q175 mice cell-autonomously decreases microglial expression of disease-associated genes and non-cell-autonomously mitigates astrogliosis and motor deterioration.
J Neuroinflammation
; 21(1): 66, 2024 Mar 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-38459557
4.
Striatal Cholinergic Dysregulation after Neonatal Decrease in X-Linked Dystonia Parkinsonism-Related TAF1 Isoforms.
Mov Disord
; 36(12): 2780-2794, 2021 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-34403156
5.
N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Amino Acids
; 53(12): 1927-1939, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34089390
6.
Insulin-like growth factor 2 (IGF2) protects against Huntington's disease through the extracellular disposal of protein aggregates.
Acta Neuropathol
; 140(5): 737-764, 2020 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32642868
7.
KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
Proc Natl Acad Sci U S A
; 114(23): E4676-E4685, 2017 06 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-28533375
8.
Novel probes for label-free detection of neurodegenerative GGGGCC repeats associated with amyotrophic lateral sclerosis.
Anal Bioanal Chem
; 411(26): 6995-7003, 2019 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-31435686
9.
Proteolytic cleavage of ataxin-7 promotes SCA7 retinal degeneration and neurological dysfunction.
Hum Mol Genet
; 24(14): 3908-17, 2015 Jul 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-25859008
10.
Integration-independent Transgenic Huntington Disease Fragment Mouse Models Reveal Distinct Phenotypes and Life Span in Vivo.
J Biol Chem
; 290(31): 19287-306, 2015 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-26025364
11.
Correction to: N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties.
Amino Acids
; 53(12): 1941, 2021 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-34286353
12.
A genome-scale RNA-interference screen identifies RRAS signaling as a pathologic feature of Huntington's disease.
PLoS Genet
; 8(11): e1003042, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23209424
13.
Brain transcriptomic, metabolic and mitohormesis properties associated with N-propargylglycine treatment: A prevention strategy against neurodegeneration.
Brain Res
; 1826: 148733, 2024 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-38128812
14.
Therapeutic targeting of HYPDH/PRODH2 with N-propargylglycine offers a Hyperoxaluria treatment opportunity.
Biochim Biophys Acta Mol Basis Dis
; 1870(1): 166848, 2024 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37586438
15.
OXR1 maintains the retromer to delay brain aging under dietary restriction.
Nat Commun
; 15(1): 467, 2024 Jan 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-38212606
16.
Single-cell transcriptomics reveals colonic immune perturbations during amyloid-ß driven Alzheimer's disease in mice.
bioRxiv
; 2024 Jan 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-38352325
17.
Caspase-6 activity in a BACHD mouse modulates steady-state levels of mutant huntingtin protein but is not necessary for production of a 586 amino acid proteolytic fragment.
J Neurosci
; 32(22): 7454-65, 2012 May 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22649225
18.
Inhibition of lipid signaling enzyme diacylglycerol kinase epsilon attenuates mutant huntingtin toxicity.
J Biol Chem
; 287(25): 21204-13, 2012 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22511757
19.
Mass spectrometric identification of novel lysine acetylation sites in huntingtin.
Mol Cell Proteomics
; 10(10): M111.009829, 2011 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-21685499
20.
Molecular and Cellular Crosstalk between Bone and Brain: Accessing Bidirectional Neural and Musculoskeletal Signaling during Aging and Disease.
J Bone Metab
; 30(1): 1-29, 2023 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-36950837