Detalles de la búsqueda
1.
Mechanistic In Vitro Studies Indicate that the Clinical Drug-Drug Interaction between Telithromycin and Simvastatin Acid Is Driven by Time-Dependent Inhibition of CYP3A4 with Minimal Effect on OATP1B1.
Drug Metab Dispos
; 47(1): 1-8, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30348903
2.
Solitary Inhibition of the Breast Cancer Resistance Protein Efflux Transporter Results in a Clinically Significant Drug-Drug Interaction with Rosuvastatin by Causing up to a 2-Fold Increase in Statin Exposure.
Drug Metab Dispos
; 44(3): 398-408, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-26700956
3.
Rosuvastatin pharmacokinetics and pharmacogenetics in Caucasian and Asian subjects residing in the United States.
Eur J Clin Pharmacol
; 71(3): 329-40, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25630984
4.
Impact of ABCG2 and SLCO1B1 polymorphisms on pharmacokinetics of rosuvastatin, atorvastatin and simvastatin acid in Caucasian and Asian subjects: a class effect?
Eur J Clin Pharmacol
; 71(3): 341-55, 2015 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25673568
5.
Mechanistic in vitro studies indicate that the clinical drug-drug interactions between protease inhibitors and rosuvastatin are driven by inhibition of intestinal BCRP and hepatic OATP1B1 with minimal contribution from OATP1B3, NTCP and OAT3.
Pharmacol Res Perspect
; 11(2): e01060, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36811234
6.
Studying the right transporter at the right time: an in vitro strategy for assessing drug-drug interaction risk during drug discovery and development.
Expert Opin Drug Metab Toxicol
; 18(10): 619-655, 2022 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-36205497
7.
The utility of in vitro data in making accurate predictions of human P-glycoprotein-mediated drug-drug interactions: a case study for AZD5672.
Drug Metab Dispos
; 39(2): 275-82, 2011 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-21075975
8.
Validation of membrane vesicle-based breast cancer resistance protein and multidrug resistance protein 2 assays to assess drug transport and the potential for drug-drug interaction to support regulatory submissions.
Xenobiotica
; 41(9): 764-83, 2011 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-21612343
9.
Mechanistic in vitro studies confirm that inhibition of the renal apical efflux transporter multidrug and toxin extrusion (MATE) 1, and not altered absorption, underlies the increased metformin exposure observed in clinical interactions with cimetidine, trimethoprim or pyrimethamine.
Pharmacol Res Perspect
; 5(5)2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28971610
10.
Effects of Fostamatinib on the Pharmacokinetics of Digoxin (a P-Glycoprotein Substrate): Results From in Vitro and Phase I Clinical Studies.
Clin Ther
; 37(12): 2811-22, 2015 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-26514315
11.
The use of bioreactors as in vitro models in pharmaceutical research.
Drug Discov Today
; 18(19-20): 922-35, 2013 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-23748137
12.
Prediction of the in vivo OATP1B1-mediated drug-drug interaction potential of an investigational drug against a range of statins.
Eur J Pharm Sci
; 47(1): 244-55, 2012 Aug 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-22538052
13.
In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate.
Eur J Pharm Sci
; 43(1-2): 41-9, 2011 May 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-21440623
14.
Relative and absolute quantitative expression profiling of cytochromes P450 using isotope-coded affinity tags.
Proteomics
; 6(6): 1934-47, 2006 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-16479536
15.
Increased constitutive c-Jun N-terminal kinase signaling in mice lacking glutathione S-transferase Pi.
J Biol Chem
; 278(25): 22243-9, 2003 Jun 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-12646564
16.
Protein expression profiling of glutathione S-transferase pi null mice as a strategy to identify potential markers of resistance to paracetamol-induced toxicity in the liver.
Proteomics
; 3(2): 191-207, 2003 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-12601812
17.
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice.
Hepatology
; 39(5): 1267-76, 2004 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-15122755
18.
Activation of hepatic Nrf2 in vivo by acetaminophen in CD-1 mice
Hepatology
; 39(5): 1267-1276, Apr 2004. grafilus
Artículo
en Inglés
| MedCarib | ID: med-17556
Resultados
1 -
18
de 18
1
Próxima >
>>