Detalles de la búsqueda
1.
Discovery of tetrahydroisoquinoline-based bivalent heterodimeric IAP antagonists.
Bioorg Med Chem Lett
; 24(21): 5022-9, 2014 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25278234
2.
Development of a carbon-14 labeling approach to support disposition studies with a pegylated biologic.
Drug Metab Dispos
; 40(9): 1677-85, 2012 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-22627466
3.
Discovery of anticancer agents of diverse natural origin.
Pure Appl Chem
; 81(6): 1051-1063, 2009 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20046887
4.
Cellular and in vivo activity of JNJ-28871063, a nonquinazoline pan-ErbB kinase inhibitor that crosses the blood-brain barrier and displays efficacy against intracranial tumors.
Mol Pharmacol
; 73(2): 338-48, 2008 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-17975007
5.
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(18): 5130-3, 2008 Sep 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18718756
6.
4-Amino-6-arylamino-pyrimidine-5-carbaldehyde hydrazones as potent ErbB-2/EGFR dual kinase inhibitors.
Bioorg Med Chem Lett
; 18(16): 4615-9, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18653333
7.
A novel 5-[1,3,4-oxadiazol-2-yl]-N-aryl-4,6-pyrimidine diamine having dual EGFR/HER2 kinase activity: design, synthesis, and biological activity.
Bioorg Med Chem Lett
; 18(17): 4896-9, 2008 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18678484
8.
Discovery of novel 4-amino-6-arylaminopyrimidine-5-carbaldehyde oximes as dual inhibitors of EGFR and ErbB-2 protein tyrosine kinases.
Bioorg Med Chem Lett
; 18(12): 3495-9, 2008 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18508264
9.
The in vitro and in vivo effects of JNJ-7706621: a dual inhibitor of cyclin-dependent kinases and aurora kinases.
Cancer Res
; 65(19): 9038-46, 2005 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16204078
10.
Role of the ABCG2 drug transporter in the resistance and oral bioavailability of a potent cyclin-dependent kinase/Aurora kinase inhibitor.
Mol Cancer Ther
; 5(10): 2459-67, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17041089
11.
1-Acyl-1H-[1,2,4]triazole-3,5-diamine analogues as novel and potent anticancer cyclin-dependent kinase inhibitors: synthesis and evaluation of biological activities.
J Med Chem
; 48(13): 4208-11, 2005 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-15974571
12.
Synthesis and identification of [1,3,5]triazine-pyridine biheteroaryl as a novel series of potent cyclin-dependent kinase inhibitors.
J Med Chem
; 48(14): 4535-46, 2005 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-15999992
13.
Synthesis and discovery of pyrazine-pyridine biheteroaryl as a novel series of potent vascular endothelial growth factor receptor-2 inhibitors.
J Med Chem
; 48(6): 1886-900, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771433
14.
Synthesis and structure-activity relationships of pyrazine-pyridine biheteroaryls as novel, potent, and selective vascular endothelial growth factor receptor-2 inhibitors.
J Med Chem
; 48(15): 4892-909, 2005 Jul 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-16033269
15.
(6,7-Dimethoxy-2,4-dihydroindeno[1,2-c]pyrazol-3-yl)phenylamines: platelet-derived growth factor receptor tyrosine kinase inhibitors with broad antiproliferative activity against tumor cells.
J Med Chem
; 48(26): 8163-73, 2005 Dec 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-16366598
16.
Novel indolylindazolylmaleimides as inhibitors of protein kinase C-beta: synthesis, biological activity, and cardiovascular safety.
J Med Chem
; 48(6): 1725-8, 2005 Mar 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-15771419
17.
The discovery of macrocyclic XIAP antagonists from a DNA-programmed chemistry library, and their optimization to give lead compounds with in vivo antitumor activity.
J Med Chem
; 58(6): 2855-61, 2015 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-25695766
18.
Discovery of potent heterodimeric antagonists of inhibitor of apoptosis proteins (IAPs) with sustained antitumor activity.
J Med Chem
; 58(3): 1556-62, 2015 Feb 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-25584393
19.
Synthesis and discovery of macrocyclic polyoxygenated bis-7-azaindolylmaleimides as a novel series of potent and highly selective glycogen synthase kinase-3beta inhibitors.
J Med Chem
; 46(19): 4021-31, 2003 Sep 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-12954055
20.
Structures of adnectin/protein complexes reveal an expanded binding footprint.
Structure
; 20(2): 259-69, 2012 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-22325775