Detalles de la búsqueda
1.
The Disposition and Metabolism of Bempedoic Acid, a Potent Inhibitor of ATP Citrate Lyase, in Healthy Human Subjects.
Drug Metab Dispos
; 51(5): 599-609, 2023 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36878717
2.
Population pharmacokinetic and pharmacokinetic-pharmacodynamic modeling of bempedoic acid and low-density lipoprotein cholesterol in healthy subjects and patients with dyslipidemia.
J Pharmacokinet Pharmacodyn
; 50(5): 351-364, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37243877
3.
Population pharmacokinetics and exposure-response modeling and simulation for evolocumab in healthy volunteers and patients with hypercholesterolemia.
J Pharmacokinet Pharmacodyn
; 45(3): 505-522, 2018 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-29736889
4.
Intestinal and hepatic first-pass extraction of the 11ß-HSD1 inhibitor AMG 221 in rats with chronic vascular catheters.
Xenobiotica
; 44(3): 264-9, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-23517558
5.
Activity-based exposure comparisons among humans and nonclinical safety testing species in an extensively metabolized drug candidate.
Xenobiotica
; 43(7): 617-27, 2013 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-23244593
6.
Phase 1, Single- and Multiple-Ascending-Dose, Food-Effect, and East Asian Subject Studies to Assess the Pharmacokinetics, Safety, and Tolerability of Bempedoic Acid, a Selective Inhibitor of Adenosine Triphosphate Citrate Lyase.
Clin Pharmacol Drug Dev
; 12(10): 1022-1035, 2023 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-37477389
7.
Physiologically Based Pharmacokinetic Model Development and Verification for Bioequivalence Testing of Bempedoic Acid Oral Suspension and Reference Tablet Formulation.
Pharmaceutics
; 15(5)2023 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-37242718
8.
Regiospecific and stereospecific triangulation of the structures of metabolites formed by sequential metabolism at multiple prochiral centers.
Drug Metab Dispos
; 40(5): 928-42, 2012 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-22328582
9.
Predicting the drug interaction potential of AMG 853, a dual antagonist of the D-prostanoid and chemoattractant receptor-homologous molecule expressed on T helper 2 cells receptors.
Drug Metab Dispos
; 40(12): 2239-49, 2012 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-22930276
10.
A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc Natl Acad Sci U S A
; 106(24): 9820-5, 2009 Jun 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-19443683
11.
Pharmacokinetics of bempedoic acid in patients with renal impairment.
Clin Transl Sci
; 15(3): 789-798, 2022 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34800002
12.
Pharmacodynamic effect of bempedoic acid and statin combinations: predictions from a dose-response model.
Eur Heart J Cardiovasc Pharmacother
; 8(6): 578-586, 2022 Sep 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-34448822
13.
Absence of effect of steady state bempedoic acid on cardiac repolarization: Results of a thorough QT/QTc study in healthy volunteers.
Clin Transl Sci
; 14(6): 2487-2496, 2021 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34463032
14.
Influence of Renal Function on Evolocumab Exposure, Pharmacodynamics, and Safety.
Clin Pharmacol Drug Dev
; 8(3): 281-289, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30676701
15.
2-amino-1,3-thiazol-4(5H)-ones as potent and selective 11beta-hydroxysteroid dehydrogenase type 1 inhibitors: enzyme-ligand co-crystal structure and demonstration of pharmacodynamic effects in C57Bl/6 mice.
J Med Chem
; 51(10): 2933-43, 2008 May 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-18419108
16.
Cinacalcet does not affect the activity of cytochrome P450 3A enzymes, a metabolic pathway for common immunosuppressive agents : a randomized, open-label, crossover, single-centre study in healthy volunteers.
Drugs R D
; 9(5): 335-43, 2008.
Artículo
en Inglés
| MEDLINE | ID: mdl-18721002
17.
Clinical Pharmacokinetics and Pharmacodynamics of Evolocumab, a PCSK9 Inhibitor.
Clin Pharmacokinet
; 57(7): 769-779, 2018 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-29353350
18.
Comparison of LDL-C Reduction Using Different Evolocumab Doses and Intervals: Biological Insights and Treatment Implications.
J Cardiovasc Pharmacol Ther
; 23(5): 423-432, 2018 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-29768954
19.
Evolution of a highly selective and potent 2-(pyridin-2-yl)-1,3,5-triazine Tie-2 kinase inhibitor.
J Med Chem
; 50(4): 611-26, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253678
20.
Alkynylpyrimidine amide derivatives as potent, selective, and orally active inhibitors of Tie-2 kinase.
J Med Chem
; 50(4): 627-40, 2007 Feb 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-17253679