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1.
Nonclinical safety assessment of a synthetic peptide thrombopoietin agonist: effects on platelets, bone homeostasis, and immunogenicity and the implications for clinical safety monitoring of adverse bone effects.
Int J Toxicol
; 30(4): 385-404, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21832269
2.
Impact on farnesyltransferase inhibition of 4-chlorophenyl moiety replacement in the Zarnestra series.
Eur J Med Chem
; 42(5): 702-14, 2007 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-17316920
3.
Effects of the farnesyl transferase inhibitor R115777 (Zarnestra) on mammary carcinogenesis: prevention, therapy, and role of HaRas mutations.
Mol Cancer Ther
; 5(4): 1073-8, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16648579
4.
Chemoprevention of benzo(a)pyrene-induced lung tumors in mice by the farnesyltransferase inhibitor R115777.
Clin Cancer Res
; 9(5): 1927-30, 2003 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-12738751
5.
Farnesyl protein transferase inhibitor ZARNESTRA R115777 - history of a discovery.
Curr Top Med Chem
; 3(10): 1095-102, 2003.
Artículo
en Inglés
| MEDLINE | ID: mdl-12769710
6.
Discovery and clinical evaluation of 1-{N-[2-(amidinoaminooxy)ethyl]amino}carbonylmethyl-6-methyl-3-[2,2-difluoro-2-phenylethylamino]pyrazinone (RWJ-671818), a thrombin inhibitor with an oxyguanidine P1 motif.
J Med Chem
; 53(4): 1843-56, 2010 Feb 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20102150
7.
Interactions of abiraterone, eplerenone, and prednisolone with wild-type and mutant androgen receptor: a rationale for increasing abiraterone exposure or combining with MDV3100.
Cancer Res
; 73(9): 2926, 2013 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-23610449
8.
Efficacy of the farnesyltransferase inhibitor R115777 in a rat mammary tumor model: role of Ha-ras mutations and use of microarray analysis in identifying potential targets.
Carcinogenesis
; 27(7): 1420-31, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16403772
9.
Phase I trial and pharmacokinetic study of the farnesyltransferase inhibitor tipifarnib in children with refractory solid tumors or neurofibromatosis type I and plexiform neurofibromas.
J Clin Oncol
; 24(3): 507-16, 2006 Jan 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-16421428
10.
Novel beta-(imidazol-4-yl)-beta-amino acids: solid-phase synthesis and study of their inhibitory activity against geranylgeranyl protein transferase type I.
Bioorg Med Chem Lett
; 15(6): 1713-9, 2005 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15745827
11.
4-methyl-1,2,4-triazol-3-yl heterocycle as an alternative to the 1-methylimidazol-5-yl moiety in the farnesyltransferase inhibitor ZARNESTRA.
Bioorg Med Chem Lett
; 13(24): 4361-4, 2003 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14643326
12.
5-imidazolyl-quinolinones, -quinazolinones and -benzo-azepinones as farnesyltransferase inhibitors.
Bioorg Med Chem Lett
; 13(9): 1543-7, 2003 May 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-12699751
13.
Substituted azoloquinolines and -quinazolines as new potent farnesyl protein transferase inhibitors.
Bioorg Med Chem Lett
; 13(24): 4365-9, 2003 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-14643327
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