Búsqueda | Biblioteca Virtual en Salud

1.

A drug-drug interaction study and physiologically based pharmacokinetic modelling to assess the effect of an oral 5-lipoxygenase activating protein inhibitor on the pharmacokinetics of oral midazolam.

Knöchel, Jane; Panduga, Vijender; Nelander, Karin; Heijer, Maria; Lindstedt, Eva-Lotte; Ali, Hodan; Aurell, Malin; Ödesjö, Helena; Forte, Pablo; Connolly, Kat; Ericsson, Hans; MacPhee, Iain.

Br J Clin Pharmacol ; 2024 Jun 03.

Artículo en Inglés | MEDLINE | ID: mdl-38830622

2.

Mass Balance and Absorption, Distribution, Metabolism, and Excretion Properties of Balcinrenone following Oral Administration in Combination with Intravenous Microtracer in Healthy Subjects.

Lindmark, Bo; Li, Xue-Qing; Bhattacharya, Chandrali; Housler, Greggory; Heijer, Maria; Bragg, Ryan A; Gränfors, Malin; Pelay-Gimeno, Marta; Vaes, Wouter H J; Menakuru, Somasekhara; Pizzato, Patricia Ely; Ericsson, Hans; Johansson, Susanne.

Drug Metab Dispos ; 51(8): 995-1004, 2023 Aug.

Artículo en Inglés | MEDLINE | ID: mdl-37407094

3.

Safety, tolerability, pharmacokinetics and effect on serum uric acid of the myeloperoxidase inhibitor AZD4831 in a randomized, placebo-controlled, phase I study in healthy volunteers.

Gan, Li-Ming; Lagerström-Fermér, Maria; Ericsson, Hans; Nelander, Karin; Lindstedt, Eva-Lotte; Michaëlsson, Erik; Kjaer, Magnus; Heijer, Maria; Whatling, Carl; Fuhr, Rainard.

Br J Clin Pharmacol ; 85(4): 762-770, 2019 04.

Artículo en Inglés | MEDLINE | ID: mdl-30618054

4.

Physiologically Based Pharmacokinetic Model of Itraconazole and Two of Its Metabolites to Improve the Predictions and the Mechanistic Understanding of CYP3A4 Drug-Drug Interactions.

Prieto Garcia, Luna; Janzén, David; Kanebratt, Kajsa P; Ericsson, Hans; Lennernäs, Hans; Lundahl, Anna.

Drug Metab Dispos ; 46(10): 1420-1433, 2018 10.

Artículo en Inglés | MEDLINE | ID: mdl-30068519

5.

Clinical safety, tolerability, pharmacokinetics and effects on urinary electrolyte excretion of AZD9977, a novel, selective mineralocorticoid receptor modulator.

Erlandsson, Fredrik; Albayaty, Muna; Chialda, Ligia; Ericsson, Hans; Amilon, Carl; Nelander, Karin; Jansson-Löfmark, Rasmus; Wernevik, Linda; Kjaer, Magnus; Bamberg, Krister; Hartleib-Geschwindner, Judith.

Br J Clin Pharmacol ; 84(7): 1486-1493, 2018 07.

Artículo en Inglés | MEDLINE | ID: mdl-29468715

6.

The myeloperoxidase inhibitor mitiperstat (AZD4831) does not prolong the QT interval at expected therapeutic doses.

Parkinson, Joanna; Sundell, Jesper; Rekic, Dinko; Nelander, Karin; Ericsson, Hans; Ebrahimi, Ahmad; Dota, Corina; Sunnåker, Mikael.

Pharmacol Res Perspect ; 12(2): e1184, 2024 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-38445541

7.

Rationale and design of ENDEAVOR: A sequential phase 2b-3 randomized clinical trial to evaluate the effect of myeloperoxidase inhibition on symptoms and exercise capacity in heart failure with preserved or mildly reduced ejection fraction.

Lund, Lars H; Lam, Carolyn S P; Pizzato, Patricia E; Gabrielsen, Anders; Michaëlsson, Erik; Nelander, Karin; Ericsson, Hans; Holden, Julie; Folkvaljon, Folke; Mattsson, Andrea; Collén, Anna; Aurell, Malin; Whatling, Carl; Baldus, Stephan; Drelich, Grzegorz; Goudev, Assen; Merkely, Béla; Bergh, Niklas; Shah, Sanjiv J.

Eur J Heart Fail ; 25(9): 1696-1707, 2023 09.

Artículo en Inglés | MEDLINE | ID: mdl-37470101

8.

Tolerability, pharmacokinetics, and pharmacodynamics of the glucokinase activator AZD1656, after single ascending doses in healthy subjects during euglycemic clamp.

Ericsson, Hans; Röshammar, Daniel; Wollbratt, Maria; Heijer, Maria; Persson, Maria; Ueda, Shinya; Leonsson-Zachrisson, Maria; Norjavaara, Ensio.

Int J Clin Pharmacol Ther ; 50(11): 765-77, 2012 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-22943931

9.

Design of FLAIR: a Phase 2b Study of the 5-Lipoxygenase Activating Protein Inhibitor AZD5718 in Patients With Proteinuric CKD.

Heerspink, Hiddo J L; Law, Gordon; Psachoulia, Konstantina; Connolly, Kathleen; Whatling, Carl; Ericsson, Hans; Knöchel, Jane; Lindstedt, Eva-Lotte; MacPhee, Iain.

Kidney Int Rep ; 6(11): 2803-2810, 2021 Nov.

Artículo en Inglés | MEDLINE | ID: mdl-34805632

10.

Pharmacokinetics, Pharmacodynamics, and Tolerability of AZD5718, an Oral 5-Lipoxygenase-Activating Protein (FLAP) Inhibitor, in Healthy Japanese Male Subjects.

Knöchel, Jane; Nelander, Karin; Heijer, Maria; Lindstedt, Eva-Lotte; Forsberg, Gun-Britt; Whatling, Carl; Shimada, Hitoshi; Han, David S; Gabrielsen, Anders; Garkaviy, Pavlo; Ericsson, Hans.

Clin Drug Investig ; 41(10): 895-905, 2021 Oct.

Artículo en Inglés | MEDLINE | ID: mdl-34546534

11.

Early Clinical Experience With AZD4831, A Novel Myeloperoxidase Inhibitor, Developed for Patients With Heart Failure With Preserved Ejection Fraction.

Nelander, Karin; Lagerstrom-Fermer, Maria; Amilon, Carl; Michaëlsson, Erik; Heijer, Maria; Kjaer, Magnus; Russell, Muir; Han, David; Lindstedt, Eva-Lotte; Whatling, Carl; Gan, Li-Ming; Ericsson, Hans.

Clin Transl Sci ; 14(3): 812-819, 2021 05.

Artículo en Inglés | MEDLINE | ID: mdl-32770730

12.

Phase 1 Pharmacokinetic Study of AZD5718 in Healthy Volunteers: Effects of Coadministration With Rosuvastatin, Formulation and Food on Oral Bioavailability.

Ericsson, Hans; Nelander, Karin; Heijer, Maria; Kjaer, Magnus; Lindstedt, Eva-Lotte; Albayaty, Muna; Forte, Pablo; Lagerström-Fermér, Maria; Skrtic, Stanko.

Clin Pharmacol Drug Dev ; 9(3): 411-421, 2020 04.

Artículo en Inglés | MEDLINE | ID: mdl-31793171

13.

Safety, Tolerability, and Pharmacokinetics of the Mineralocorticoid Receptor Modulator AZD9977 in Healthy Men: A Phase I Multiple Ascending Dose Study.

Whittaker, Andrew; Kragh, Åsa M; Hartleib-Geschwindner, Judith; Albayaty, Muna; Backlund, Anna; Greasley, Peter J; Heijer, Maria; Kjaer, Magnus; Forte, Pablo; Unwin, Robert; Wernevik, Linda; Ericsson, Hans.

Clin Transl Sci ; 13(2): 275-283, 2020 03.

Artículo en Inglés | MEDLINE | ID: mdl-31584739

14.

Discovery and Early Clinical Development of an Inhibitor of 5-Lipoxygenase Activating Protein (AZD5718) for Treatment of Coronary Artery Disease.

Pettersen, Daniel; Broddefalk, Johan; Emtenäs, Hans; Hayes, Martin A; Lemurell, Malin; Swanson, Marianne; Ulander, Johan; Whatling, Carl; Amilon, Carl; Ericsson, Hans; Westin Eriksson, Annika; Granberg, Kenneth; Plowright, Alleyn T; Shamovsky, Igor; Dellsèn, Anita; Sundqvist, Monica; Någård, Mats; Lindstedt, Eva-Lotte.

J Med Chem ; 62(9): 4312-4324, 2019 05 09.

Artículo en Inglés | MEDLINE | ID: mdl-30869888

15.

Mechanistic modelling of tesaglitazar pharmacokinetic data in subjects with various degrees of renal function--evidence of interconversion.

Hamrén, Bengt; Ericsson, Hans; Samuelsson, Ola; Karlsson, Mats O.

Br J Clin Pharmacol ; 65(6): 855-63, 2008 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-18294322

16.

Initial Clinical Experience with AZD5718, a Novel Once Daily Oral 5-Lipoxygenase Activating Protein Inhibitor.

Ericsson, Hans; Nelander, Karin; Lagerstrom-Fermer, Maria; Balendran, Clare; Bhat, Maria; Chialda, Ligia; Gan, Li-Ming; Heijer, Maria; Kjaer, Magnus; Lambert, John; Lindstedt, Eva-Lotte; Forsberg, Gun-Britt; Whatling, Carl; Skrtic, Stanko.

Clin Transl Sci ; 11(3): 330-338, 2018 05.

Artículo en Inglés | MEDLINE | ID: mdl-29517132

17.

Exploring the insulin secretory properties of the PGD2-GPR44/DP2 axis in vitro and in a randomized phase-1 trial of type 2 diabetes patients.

Skrtic, Stanko; Tyrberg, Björn; Broberg, Malin; Ericsson, Hans; Schnecke, Volker; Kjaer, Magnus; Hompesch, Marcus; Andersson, Eva-Marie; Ryberg, Erik; Aivazidis, Alexander; Wennberg Huldt, Charlotte; Löfgren, Lars; Morrow, Linda; Parkinson, Joanna; Rydén-Bergsten, Tina; Watkins, Elaine; Sörhede Winzell, Maria.

PLoS One ; 13(12): e0208998, 2018.

Artículo en Inglés | MEDLINE | ID: mdl-30557325

18.

Antibiotic sensitivity testing. 1971.

Ericsson, Hans M; Sherries, John C.

APMIS ; 115(5): 609-18; discussion 619-20, 2007 May.

Artículo en Inglés | MEDLINE | ID: mdl-17504424

19.

The glucokinase activator AZD6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food.

Ericsson, Hans; Sjöberg, Folke; Heijer, Maria; Dorani, Hassan; Johansson, Peter; Wollbratt, Maria; Norjavaara, Ensio.

Diabetes Res Clin Pract ; 98(3): 436-44, 2012 Dec.

Artículo en Inglés | MEDLINE | ID: mdl-23010558

20.

Glucokinase activators AZD6370 and AZD1656 do not affect the central counterregulatory response to hypoglycemia in healthy males.

Norjavaara, Ensio; Ericsson, Hans; Sjöberg, Folke; Leonsson-Zachrisson, Maria; Sjöstrand, Mikaela; Morrow, Linda A; Hompesch, Marcus.

J Clin Endocrinol Metab ; 97(9): 3319-25, 2012 Sep.

Artículo en Inglés | MEDLINE | ID: mdl-22723318

Biblioteca Virtual en Salud

Hipertensión

Su selección (0)

Formato de exportación:

Exportar: