Detalles de la búsqueda
1.
A Phase 1/2A trial of idroxioleic acid: first-in-class sphingolipid regulator and glioma cell autophagy inducer with antitumor activity in refractory glioma.
Br J Cancer
; 129(5): 811-818, 2023 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-37488446
2.
The Antimicrobial Peptide 1018-K6 Interacts Distinctly with Eukaryotic and Bacterial Membranes, the Basis of Its Specificity and Bactericidal Activity.
Int J Mol Sci
; 23(20)2022 Oct 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-36293249
3.
HCA (2-Hydroxy-Docosahexaenoic Acid) Induces Apoptosis and Endoplasmic Reticulum Stress in Pancreatic Cancer Cells.
Int J Mol Sci
; 23(17)2022 Aug 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-36077299
4.
Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues.
Int J Mol Sci
; 20(9)2019 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31052427
5.
Triacylglycerol mimetics regulate membrane interactions of glycogen branching enzyme: implications for therapy.
J Lipid Res
; 58(8): 1598-1612, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28630259
6.
Membrane-lipid therapy: A historical perspective of membrane-targeted therapies - From lipid bilayer structure to the pathophysiological regulation of cells.
Biochim Biophys Acta Biomembr
; 1859(9 Pt B): 1493-1506, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28577973
7.
WITHDRAWN: Membrane-lipid therapy: A historical perspective of membrane-targeted therapies-From lipid bilayer structure to the pathophysiological regulation of cells.
Biochim Biophys Acta Biomembr
; 2017 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28476630
8.
The hydroxylated form of docosahexaenoic acid (DHA-H) modifies the brain lipid composition in a model of Alzheimer's disease, improving behavioral motor function and survival.
Biochim Biophys Acta Biomembr
; 1859(9 Pt B): 1596-1603, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28284721
9.
Role of the C-terminal basic amino acids and the lipid anchor of the Gγ2 protein in membrane interactions and cell localization.
Biochim Biophys Acta Biomembr
; 1859(9 Pt B): 1536-1547, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28235469
10.
G protein-membrane interactions II: Effect of G protein-linked lipids on membrane structure and G protein-membrane interactions.
Biochim Biophys Acta Biomembr
; 1859(9 Pt B): 1526-1535, 2017 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-28411171
11.
Structural basis of glycogen branching enzyme deficiency and pharmacologic rescue by rational peptide design.
Hum Mol Genet
; 24(20): 5667-76, 2015 Oct 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26199317
12.
G protein-membrane interactions I: Gαi1 myristoyl and palmitoyl modifications in protein-lipid interactions and its implications in membrane microdomain localization.
Biochim Biophys Acta
; 1851(11): 1511-20, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26253820
13.
Optimized Protocol To Analyze Changes in the Lipidome of Xenografts after Treatment with 2-Hydroxyoleic Acid.
Anal Chem
; 88(1): 1022-9, 2016 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26607740
14.
The effect of natural and synthetic fatty acids on membrane structure, microdomain organization, cellular functions and human health.
Biochim Biophys Acta
; 1838(6): 1518-28, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24388951
15.
Regulation of the cancer cell membrane lipid composition by NaCHOleate: effects on cell signaling and therapeutical relevance in glioma.
Biochim Biophys Acta
; 1838(6): 1619-27, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24525074
16.
Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease.
Biochim Biophys Acta
; 1838(6): 1680-92, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24374316
17.
Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets.
Biochim Biophys Acta
; 1838(6): 1628-37, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24412218
18.
The unfolded protein response in the therapeutic effect of hydroxy-DHA against Alzheimer's disease.
Apoptosis
; 20(5): 712-24, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25663172
19.
The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism.
J Pharmacol Exp Ther
; 354(2): 213-24, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26065701
20.
2-Hydroxyoleate, a nontoxic membrane binding anticancer drug, induces glioma cell differentiation and autophagy.
Proc Natl Acad Sci U S A
; 109(22): 8489-94, 2012 May 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-22586083