Detalles de la búsqueda
1.
Pharmacologic inhibition of lipogenesis for the treatment of NAFLD.
J Hepatol
; 80(2): 362-377, 2024 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-37977245
2.
A phase 2a, randomized, double-blind, placebo-controlled, three-arm, parallel-group study to assess the efficacy, safety, tolerability and pharmacodynamics of PF-06835919 in patients with non-alcoholic fatty liver disease and type 2 diabetes.
Diabetes Obes Metab
; 25(4): 992-1001, 2023 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-36515213
3.
Discovery of spirocyclic-diamine inhibitors of mammalian acetyl CoA-carboxylase.
Bioorg Med Chem Lett
; 25(22): 5352-6, 2015 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26411795
4.
Investigation of pharmacokinetic drug interaction between clesacostat and DGAT2 inhibitor ervogastat in healthy adult participants.
Clin Transl Sci
; 17(2): e13687, 2024 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-38362827
5.
Inhibition of Acetyl-CoA Carboxylase Causes Malformations in Rats and Rabbits: Comparison of Mammalian Findings and Alternative Assays.
Toxicol Sci
; 179(2): 183-194, 2021 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-33247737
6.
ACC inhibitor alone or co-administered with a DGAT2 inhibitor in patients with non-alcoholic fatty liver disease: two parallel, placebo-controlled, randomized phase 2a trials.
Nat Med
; 27(10): 1836-1848, 2021 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-34635855
7.
Pharmacologic inhibition of ketohexokinase prevents fructose-induced metabolic dysfunction.
Mol Metab
; 48: 101196, 2021 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-33667726
8.
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of a Liver-Targeting Acetyl-CoA Carboxylase Inhibitor (PF-05221304): A Three-Part Randomized Phase 1 Study.
Clin Pharmacol Drug Dev
; 9(4): 514-526, 2020 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-32065514
9.
Acetyl-CoA Carboxylase Inhibition Improves Multiple Dimensions of NASH Pathogenesis in Model Systems.
Cell Mol Gastroenterol Hepatol
; 10(4): 829-851, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32526482
10.
De novo lipogenesis is essential for platelet production in humans.
Nat Metab
; 2(10): 1163-1178, 2020 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-32929234
11.
Optimizing the Benefit/Risk of Acetyl-CoA Carboxylase Inhibitors through Liver Targeting.
J Med Chem
; 63(19): 10879-10896, 2020 10 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-32809824
12.
Metabolic Targets in Nonalcoholic Fatty Liver Disease.
Cell Mol Gastroenterol Hepatol
; 8(2): 247-267, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31004828
13.
The combination of exercise training and sodium-glucose cotransporter-2 inhibition improves glucose tolerance and exercise capacity in a rodent model of type 2 diabetes.
Metabolism
; 97: 68-80, 2019 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-31132381
14.
Targeting host metabolism by inhibition of acetyl-Coenzyme A carboxylase reduces flavivirus infection in mouse models.
Emerg Microbes Infect
; 8(1): 624-636, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-30999821
15.
Human sebum requires de novo lipogenesis, which is increased in acne vulgaris and suppressed by acetyl-CoA carboxylase inhibition.
Sci Transl Med
; 11(492)2019 05 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-31092695
16.
Small-molecule ghrelin receptor antagonists improve glucose tolerance, suppress appetite, and promote weight loss.
Endocrinology
; 148(11): 5175-85, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17656463
17.
Quinazolinone derivatives as orally available ghrelin receptor antagonists for the treatment of diabetes and obesity.
J Med Chem
; 50(21): 5202-16, 2007 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-17887659
18.
Inhibition of Acetyl-CoA Carboxylase 1 (ACC1) and 2 (ACC2) Reduces Proliferation and De Novo Lipogenesis of EGFRvIII Human Glioblastoma Cells.
PLoS One
; 12(1): e0169566, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-28081256
19.
Amyloid-lowering isocoumarins are not direct inhibitors of gamma-secretase.
Nat Cell Biol
; 4(5): E110-1; author reply E111-2, 2002 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-11988746
20.
Gamma-secretase/presenilin inhibitors for Alzheimer's disease phenocopy Notch mutations in Drosophila.
FASEB J
; 17(1): 79-81, 2003 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-12424225