Detalles de la búsqueda
1.
Structural analysis of the SAM domain of the Arabidopsis mitochondrial tRNA import receptor.
J Biol Chem
; 300(5): 107258, 2024 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-38582448
2.
A lipid site shapes the agonist response of a pentameric ligand-gated ion channel.
Nat Chem Biol
; 15(12): 1156-1164, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31591563
3.
Structure of a lipid A phosphoethanolamine transferase suggests how conformational changes govern substrate binding.
Proc Natl Acad Sci U S A
; 114(9): 2218-2223, 2017 02 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-28193899
4.
Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.
Biochim Biophys Acta Proteins Proteom
; 1866(2): 264-274, 2018 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-28844746
5.
Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry
; 54(39): 6082-92, 2015 Oct 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26356348
6.
A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 4): 862-72, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25849397
7.
Structure and inhibition of subunit I of the anthranilate synthase complex of Mycobacterium tuberculosis and expression of the active complex.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 11): 2297-308, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-26527146
8.
Alternative substrates reveal catalytic cycle and key binding events in the reaction catalysed by anthranilate phosphoribosyltransferase from Mycobacterium tuberculosis.
Biochem J
; 461(1): 87-98, 2014 Jul 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24712732
9.
Repurposing the chemical scaffold of the anti-arthritic drug Lobenzarit to target tryptophan biosynthesis in Mycobacterium tuberculosis.
Chembiochem
; 15(6): 852-64, 2014 Apr 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-24623674
10.
The substrate capture mechanism of Mycobacterium tuberculosis anthranilate phosphoribosyltransferase provides a mode for inhibition.
Biochemistry
; 52(10): 1776-87, 2013 Mar 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-23363292
11.
Purification, crystallization and preliminary X-ray studies of MbtN (Rv1346) from Mycobacterium tuberculosis.
Acta Crystallogr Sect F Struct Biol Cryst Commun
; 69(Pt 12): 1354-6, 2013 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-24316828
12.
Implications of binding mode and active site flexibility for inhibitor potency against the salicylate synthase from Mycobacterium tuberculosis.
Biochemistry
; 51(24): 4868-79, 2012 Jun 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-22607697
13.
PDBe and PDBe-KB: Providing high-quality, up-to-date and integrated resources of macromolecular structures to support basic and applied research and education.
Protein Sci
; 31(10): e4439, 2022 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-36173162
14.
A tetrameric structure is not essential for activity in dihydrodipicolinate synthase (DHDPS) from Mycobacterium tuberculosis.
Arch Biochem Biophys
; 512(2): 154-9, 2011 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21672512
15.
Conformational flexibility of EptA driven by an interdomain helix provides insights for enzyme-substrate recognition.
IUCrJ
; 8(Pt 5): 732-746, 2021 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-34584735
16.
Corrigendum: Repurposing the Chemical Scaffold of the Anti-Arthritic Drug Lobenzarit to Target Tryptophan Biosynthesis in Mycobacterium tuberculosis.
Chembiochem
; 16(5): 706, 2015 Mar 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-26177917
17.
Modulation of the Erwinia ligand-gated ion channel (ELIC) and the 5-HT3 receptor via a common vestibule site.
Elife
; 92020 01 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-31990273
18.
Crystal structure and kinetic study of dihydrodipicolinate synthase from Mycobacterium tuberculosis.
Biochem J
; 411(2): 351-60, 2008 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18062777
19.
Inhibiting dihydrodipicolinate synthase across species: towards specificity for pathogens?
Bioorg Med Chem Lett
; 18(2): 842-4, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18054225
20.
Datasets, processing and refinement details for Mtb-AnPRT: inhibitor structures with various space groups.
Data Brief
; 15: 1019-1029, 2017 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-29167811