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1.
Evaluation of Normalization Methods To Predict CYP3A4 Induction in Six Fully Characterized Cryopreserved Human Hepatocyte Preparations and HepaRG Cells.
Drug Metab Dispos
; 44(1): 50-60, 2016 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-26467767
2.
Physiologically based pharmacokinetic modeling for sequential metabolism: effect of CYP2C19 genetic polymorphism on clopidogrel and clopidogrel active metabolite pharmacokinetics.
Drug Metab Dispos
; 43(4): 510-22, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25609219
3.
Morphological behaviour and metabolic capacity of cryopreserved human primary hepatocytes cultivated in a perfused multiwell device.
Xenobiotica
; 45(1): 29-44, 2015 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-25068923
4.
Effect of deuteration on the metabolism and clearance of some pharmacologically active compounds--synthesis and in vitro metabolism of deuterated derivatives of dronedadrone.
J Labelled Comp Radiopharm
; 56(9-10): 504-12, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24285529
5.
Rational design of a novel peripherally-restricted, orally active CB(1) cannabinoid antagonist containing a 2,3-diarylpyrrole motif.
Bioorg Med Chem Lett
; 20(15): 4573-7, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20584609
6.
Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans.
Drug Metab Dispos
; 36(5): 851-62, 2008 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-18256203
7.
Ocular Drug Distribution After Topical Administration: Population Pharmacokinetic Model in Rabbits.
Eur J Drug Metab Pharmacokinet
; 42(1): 59-68, 2017 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-26820265
8.
Human hepatocyte culture.
Methods Mol Biol
; 320: 283-93, 2006.
Artículo
en Inglés
| MEDLINE | ID: mdl-16719400
9.
An inter-laboratory study to evaluate the effects of medium composition on the differentiation and barrier function of Caco-2 cell lines.
Altern Lab Anim
; 33(6): 603-18, 2005 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-16372835
10.
Evaluation of human hepatocytes under prolonged culture in a novel medium for the maintenance of hepatic differentiation: results with the model pro-inflammatory cytokine interleukin 6.
Drug Metab Lett
; 8(1): 12-8, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25313020
11.
Identification of metabolic pathways and enzyme systems involved in the in vitro human hepatic metabolism of dronedarone, a potent new oral antiarrhythmic drug.
Pharmacol Res Perspect
; 2(3): e00044, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-25505590
12.
The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction.
Methods Mol Biol
; 640: 295-308, 2010.
Artículo
en Inglés
| MEDLINE | ID: mdl-20645059
13.
Transcriptome response of enterocytes to dietary lipids: impact on cell architecture, signaling, and metabolism genes.
Am J Physiol Gastrointest Liver Physiol
; 295(5): G942-52, 2008 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-18755805
14.
In vitro metabolism of ferroquine (SSR97193) in animal and human hepatic models and antimalarial activity of major metabolites on Plasmodium falciparum.
Drug Metab Dispos
; 34(4): 667-82, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16415117
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