Búsqueda | Biblioteca Virtual en Salud

1.

Free Drug Theory - No Longer Just a Hypothesis?

Summerfield, Scott G; Yates, James W T; Fairman, David A.

Pharm Res ; 39(2): 213-222, 2022 Feb.

Artículo en Inglés | MEDLINE | ID: mdl-35112229

2.

A positron emission tomography imaging study to confirm target engagement in the lungs of patients with idiopathic pulmonary fibrosis following a single dose of a novel inhaled αvß6 integrin inhibitor.

Maher, Toby M; Simpson, Juliet K; Porter, Joanna C; Wilson, Frederick J; Chan, Robert; Eames, Rhena; Cui, Yi; Siederer, Sarah; Parry, Simon; Kenny, Julia; Slack, Robert J; Sahota, Jagdeep; Paul, Lyn; Saunders, Peter; Molyneaux, Philip L; Lukey, Pauline T; Rizzo, Gaia; Searle, Graham E; Marshall, Richard P; Saleem, Azeem; Kang'ombe, Arthur R; Fairman, David; Fahy, William A; Vahdati-Bolouri, Mitra.

Respir Res ; 21(1): 75, 2020 Mar 26.

Artículo en Inglés | MEDLINE | ID: mdl-32216814

3.

Safety, tolerability and pharmacokinetics of GSK3008348, a novel integrin αvß6 inhibitor, in healthy participants.

Maden, Charlotte H; Fairman, David; Chalker, Michelle; Costa, Maria J; Fahy, William A; Garman, Nadia; Lukey, Pauline T; Mant, Tim; Parry, Simon; Simpson, Juliet K; Slack, Robert J; Kendrick, Stuart; Marshall, Richard P.

Eur J Clin Pharmacol ; 74(6): 701-709, 2018 Jun.

Artículo en Inglés | MEDLINE | ID: mdl-29532104

4.

A pilot clinical trial of recombinant human angiotensin-converting enzyme 2 in acute respiratory distress syndrome.

Khan, Akram; Benthin, Cody; Zeno, Brian; Albertson, Timothy E; Boyd, John; Christie, Jason D; Hall, Richard; Poirier, Germain; Ronco, Juan J; Tidswell, Mark; Hardes, Kelly; Powley, William M; Wright, Tracey J; Siederer, Sarah K; Fairman, David A; Lipson, David A; Bayliffe, Andrew I; Lazaar, Aili L.

Crit Care ; 21(1): 234, 2017 09 07.

Artículo en Inglés | MEDLINE | ID: mdl-28877748

5.

Best Practices in mAb and Soluble Target Assay Selection for Quantitative Modelling and Qualitative Interpretation.

Fairman, David; Tang, Huaping.

AAPS J ; 25(1): 23, 2023 02 09.

Artículo en Inglés | MEDLINE | ID: mdl-36759378

6.

Efficacy and safety of GSK3772847 in participants with moderate-to-severe asthma with allergic fungal airway disease: A phase IIa randomized, multicenter, double-blind, sponsor-open, comparative trial.

Akinseye, Chika; Crim, Courtney; Newlands, Amy; Fairman, David.

PLoS One ; 18(2): e0281205, 2023.

Artículo en Inglés | MEDLINE | ID: mdl-36735745

7.

Safety, tolerability, and pharmacokinetics of a single ascending subcutaneous dose of GSK3772847 in healthy participants.

Pefani, Eleni; Stone, Sally; Zhu, Chang-Qing; Nunn, Carol; Fairman, David.

Pharmacol Res Perspect ; 11(2): e01054, 2023 Apr.

Artículo en Inglés | MEDLINE | ID: mdl-36846967

8.

How translational modeling in oncology needs to get the mechanism just right.

Yates, James W T; Fairman, David A.

Clin Transl Sci ; 15(3): 588-600, 2022 03.

Artículo en Inglés | MEDLINE | ID: mdl-34716976

9.

Acidic triazoles as soluble guanylate cyclase stimulators.

Roberts, Lee R; Bradley, Paul A; Bunnage, Mark E; England, Katherine S; Fairman, David; Fobian, Yvette M; Fox, David N A; Gymer, Geoff E; Heasley, Steven E; Molette, Jerome; Smith, Graham L; Schmidt, Michelle A; Tones, Michael A; Dack, Kevin N.

Bioorg Med Chem Lett ; 21(21): 6515-8, 2011 Nov 01.

Artículo en Inglés | MEDLINE | ID: mdl-21924901

10.

Inhalation by design: dual pharmacology ß-2 agonists/M3 antagonists for the treatment of COPD.

Jones, Lyn H; Baldock, Helen; Bunnage, Mark E; Burrows, Jane; Clarke, Nick; Coghlan, Michele; Entwistle, David; Fairman, David; Feeder, Neil; Fulton, Craig; Hilton, Laura; James, Kim; Jones, Rhys M; Kenyon, Amy S; Marshall, Stuart; Newman, Sandra D; Osborne, Rachel; Patel, Sheena; Selby, Matthew D; Stuart, Emilio F; Trevethick, Michael A; Wright, Karen N; Price, David A.

Bioorg Med Chem Lett ; 21(9): 2759-63, 2011 May 01.

Artículo en Inglés | MEDLINE | ID: mdl-21075627

11.

Small, non-peptide C5a receptor antagonists: part 1.

Blagg, Julian; Mowbray, Charles; Pryde, David C; Salmon, Gary; Schmid, Esther; Fairman, David; Beaumont, Kevin.

Bioorg Med Chem Lett ; 18(20): 5601-4, 2008 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-18809326

12.

Small, non-peptide C5a receptor antagonists: part 2.

Blagg, Julian; Mowbray, Charles; Pryde, David; Salmon, Gary; Fairman, David; Schmid, Esther; Beaumont, Kevin.

Bioorg Med Chem Lett ; 18(20): 5605-8, 2008 Oct 15.

Artículo en Inglés | MEDLINE | ID: mdl-18804369

13.

Engineering of a GLP-1 analogue peptide/anti-PCSK9 antibody fusion for type 2 diabetes treatment.

Chodorge, Matthieu; Celeste, Anthony J; Grimsby, Joseph; Konkar, Anish; Davidsson, Pia; Fairman, David; Jenkinson, Lesley; Naylor, Jacqueline; White, Nicholas; Seaman, Jonathan C; Dickson, Karen; Kemp, Benjamin; Spooner, Jennifer; Rossy, Emmanuel; Hornigold, David C; Trevaskis, James L; Bond, Nicholas J; London, Timothy B; Buchanan, Andrew; Vaughan, Tristan; Rondinone, Cristina M; Osbourn, Jane K.

Sci Rep ; 8(1): 17545, 2018 12 03.

Artículo en Inglés | MEDLINE | ID: mdl-30510163

14.

Corrigendum to "Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling" [International Journal of Cardiology 167 (2013) 2630-2637].

Kojonazarov, Baktybek; Sydykov, Akylbek; Pullamsetti, Soni Savai; Luitel, Himal; Dahal, Bhola K; Kosanovic, Djuro; Tian, Xia; Majewski, Matthaeus; Baumann, Christin; Evans, Steve; Phillips, Peter; Fairman, David; Davie, Neil; Wayman, Chris; Kilty, Iain; Weissmann, Norbert; Grimminger, Friedrich; Seeger, Werner; Ghofrani, Hossein Ardeschir; Schermuly, Ralph Theo.

Int J Cardiol ; 357: 152-153, 2022 Jun 15.

Artículo en Inglés | MEDLINE | ID: mdl-35367072

15.

The antianginal agent trimetazidine does not exert its functional benefit via inhibition of mitochondrial long-chain 3-ketoacyl coenzyme A thiolase.

MacInnes, Alan; Fairman, David A; Binding, Peter; Rhodes, Jo ann; Wyatt, Michael J; Phelan, Anne; Haddock, Peter S; Karran, Eric H.

Circ Res ; 93(3): e26-32, 2003 Aug 08.

Artículo en Inglés | MEDLINE | ID: mdl-12869391

16.

Effects of multikinase inhibitors on pressure overload-induced right ventricular remodeling.

Kojonazarov, Baktybek; Sydykov, Akylbek; Pullamsetti, Soni Savai; Luitel, Himal; Dahal, Bhola K; Kosanovic, Djuro; Tian, Xia; Majewski, Matthaeus; Baumann, Christin; Evans, Steve; Phillips, Peter; Fairman, David; Davie, Neil; Wayman, Chris; Kilty, Iain; Weissmann, Norbert; Grimminger, Friedrich; Seeger, Werner; Ghofrani, Hossein Ardeschir; Schermuly, Ralph Theo.

Int J Cardiol ; 167(6): 2630-7, 2013 Sep 10.

Artículo en Inglés | MEDLINE | ID: mdl-22854298

17.

Regulation of leukotriene and 5oxoETE synthesis and the effect of 5-lipoxygenase inhibitors: a mathematical modeling approach.

Karelina, Tatiana A; Zhudenkov, Kirill V; Demin, Oleg O; Svetlichny, Dmitry V; Agoram, Balaji; Fairman, David; Demin, Oleg V.

BMC Syst Biol ; 6: 141, 2012 Nov 12.

Artículo en Inglés | MEDLINE | ID: mdl-23146124

18.

Design and synthesis of inhaled p38 inhibitors for the treatment of chronic obstructive pulmonary disease.

Millan, David S; Bunnage, Mark E; Burrows, Jane L; Butcher, Kenneth J; Dodd, Peter G; Evans, Timothy J; Fairman, David A; Hughes, Samantha J; Kilty, Iain C; Lemaitre, Arnaud; Lewthwaite, Russell A; Mahnke, Axel; Mathias, John P; Philip, James; Smith, Robert T; Stefaniak, Mark H; Yeadon, Michael; Phillips, Christopher.

J Med Chem ; 54(22): 7797-814, 2011 Nov 24.

Artículo en Inglés | MEDLINE | ID: mdl-21888439

19.

Inhalation by design: novel tertiary amine muscarinic M3 receptor antagonists with slow off-rate binding kinetics for inhaled once-daily treatment of chronic obstructive pulmonary disease.

Glossop, Paul A; Watson, Christine A L; Price, David A; Bunnage, Mark E; Middleton, Donald S; Wood, Anthony; James, Kim; Roberts, Dannielle; Strang, Ross S; Yeadon, Michael; Perros-Huguet, Christelle; Clarke, Nicholas P; Trevethick, Michael A; Machin, Ian; Stuart, Emilio F; Evans, Steven M; Harrison, Anthony C; Fairman, David A; Agoram, Balaji; Burrows, Jane L; Feeder, Neil; Fulton, Craig K; Dillon, Barry R; Entwistle, David A; Spence, Fiona J.

J Med Chem ; 54(19): 6888-904, 2011 Oct 13.

Artículo en Inglés | MEDLINE | ID: mdl-21870878

20.

Negotiating Public Health in a Globalized World : Global Health Diplomacy in Action

Fairman, David.

Dordrecht; Springer Netherlands; 2012. 186 p.

Monografía en Inglés | Bibliografia | ID: bib-366962

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