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1.
Enhanced proteolysis of beta-amyloid in APP transgenic mice prevents plaque formation, secondary pathology, and premature death.
Neuron
; 40(6): 1087-93, 2003 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-14687544
2.
Effects of chronic glucocorticoid administration on insulin-degrading enzyme and amyloid-beta peptide in the aged macaque.
J Neuropathol Exp Neurol
; 64(2): 139-46, 2005 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15751228
3.
Alternative translation initiation generates a novel isoform of insulin-degrading enzyme targeted to mitochondria.
Biochem J
; 383(Pt. 3): 439-46, 2004 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-15285718
4.
Effects of prolonged angiotensin-converting enzyme inhibitor treatment on amyloid beta-protein metabolism in mouse models of Alzheimer disease.
Neurobiol Dis
; 26(1): 273-81, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17321748
5.
Loss of neprilysin function promotes amyloid plaque formation and causes cerebral amyloid angiopathy.
Am J Pathol
; 171(1): 241-51, 2007 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-17591969
6.
Decreased catalytic activity of the insulin-degrading enzyme in chromosome 10-linked Alzheimer disease families.
J Biol Chem
; 282(11): 7825-32, 2007 Mar 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-17244626
7.
Alternative splicing of human insulin-degrading enzyme yields a novel isoform with a decreased ability to degrade insulin and amyloid beta-protein.
Biochemistry
; 44(17): 6513-25, 2005 May 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-15850385
8.
Insulin-degrading enzyme regulates the levels of insulin, amyloid beta-protein, and the beta-amyloid precursor protein intracellular domain in vivo.
Proc Natl Acad Sci U S A
; 100(7): 4162-7, 2003 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12634421
9.
Partial loss-of-function mutations in insulin-degrading enzyme that induce diabetes also impair degradation of amyloid beta-protein.
Am J Pathol
; 164(4): 1425-34, 2004 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-15039230
10.
Kinetics of amyloid beta-protein degradation determined by novel fluorescence- and fluorescence polarization-based assays.
J Biol Chem
; 278(39): 37314-20, 2003 Sep 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-12867419
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