Detalles de la búsqueda
1.
Antiviral activity and in vitro mutation development pathways of MK-6186, a novel nonnucleoside reverse transcriptase inhibitor.
Antimicrob Agents Chemother
; 56(6): 3324-35, 2012 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-22391531
2.
Design and synthesis of pyridone inhibitors of non-nucleoside reverse transcriptase.
Bioorg Med Chem Lett
; 21(24): 7344-50, 2011 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22071300
3.
Distinct mutation pathways of non-subtype B HIV-1 during in vitro resistance selection with nonnucleoside reverse transcriptase inhibitors.
Antimicrob Agents Chemother
; 54(11): 4812-24, 2010 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-20805392
4.
Total synthesis, characterization, and conformational analysis of the naturally occurring hexadecapeptide integramide A and a diastereomer.
Chemistry
; 16(1): 316-27, 2010 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-19937615
5.
Biaryl ethers as potent allosteric inhibitors of reverse transcriptase and its key mutant viruses: aryl substituted pyrazole as a surrogate for the pyrazolopyridine motif.
Bioorg Med Chem Lett
; 20(15): 4328-32, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20609585
6.
Substituted tetrahydroquinolines as potent allosteric inhibitors of reverse transcriptase and its key mutants.
Bioorg Med Chem Lett
; 19(17): 5119-23, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19631528
7.
Design and synthesis of bicyclic pyrimidinones as potent and orally bioavailable HIV-1 integrase inhibitors.
J Med Chem
; 51(4): 861-74, 2008 Feb 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-18217703
8.
Design and synthesis of substituted 4-oxo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrazine-2-carboxamides, novel HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 18(2): 721-5, 2008 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18078751
9.
Synthesis of 5-(1-H or 1-alkyl-5-oxopyrrolidin-3-yl)-8-hydroxy-[1,6]-naphthyridine-7-carboxamide inhibitors of HIV-1 integrase.
Bioorg Med Chem Lett
; 18(19): 5307-10, 2008 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18774711
10.
The design and synthesis of diaryl ether second generation HIV-1 non-nucleoside reverse transcriptase inhibitors (NNRTIs) with enhanced potency versus key clinical mutations.
Bioorg Med Chem Lett
; 18(9): 2959-66, 2008 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18396399
11.
10-Hydroxy-7,8-dihydropyrazino[1',2':1,5]pyrrolo[2,3-d]pyridazine-1,9(2H,6H)-diones: potent, orally bioavailable HIV-1 integrase strand-transfer inhibitors with activity against integrase mutants.
Bioorg Med Chem Lett
; 18(16): 4581-3, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18657970
12.
Discovery and synthesis of HIV integrase inhibitors: development of potent and orally bioavailable N-methyl pyrimidones.
J Med Chem
; 50(20): 4953-75, 2007 Oct 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-17824681
13.
8-Hydroxy-3,4-dihydropyrrolo[1,2-a]pyrazine-1(2H)-one HIV-1 integrase inhibitors.
Bioorg Med Chem Lett
; 17(23): 6511-5, 2007 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-17931865
14.
Discovery of MK-8718, an HIV Protease Inhibitor Containing a Novel Morpholine Aspartate Binding Group.
ACS Med Chem Lett
; 7(7): 702-7, 2016 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27437081
15.
Complete absolute configuration of integramide A, a natural, 16-mer peptide inhibitor of HIV-1 integrase, elucidated by total synthesis.
Chembiochem
; 10(1): 87-90, 2009 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-18850604
16.
Design and synthesis of 8-hydroxy-[1,6]naphthyridines as novel inhibitors of HIV-1 integrase in vitro and in infected cells.
J Med Chem
; 46(4): 453-6, 2003 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-12570367
17.
Structure, stereochemistry, and biological activity of integramycin, a novel hexacyclic natural product produced by Actinoplanes sp. that inhibits HIV-1 integrase.
Org Lett
; 4(7): 1123-6, 2002 Apr 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-11922798
18.
Integramides A and B, two novel non-ribosomal linear peptides containing nine C(alpha)-methyl amino acids produced by fungal fermentations that are inhibitors of HIV-1 integrase.
Org Lett
; 4(9): 1431-4, 2002 May 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-11975596
19.
Isolation, structure and HIV-1 integrase inhibitory activity of exophillic acid, a novel fungal metabolite from Exophiala pisciphila.
J Antibiot (Tokyo)
; 56(12): 1018-23, 2003 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-15015729
20.
Triple HypâPro replacement in integramide A, a peptaib inhibitor of HIV-1 integrase: Effect on conformation and bioactivity.
Biopolymers
; 96(1): 49-59, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-20560143