Detalles de la búsqueda
1.
Concentration Dependence of the Unbound Partition Coefficient Kpuu and Its Application to Correct for Exposure-Related Discrepancies between Biochemical and Cellular Potency of KAT6A Inhibitors.
Drug Metab Dispos
; 48(7): 553-562, 2020 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32357973
2.
Binding Kinetics Survey of the Drugged Kinome.
J Am Chem Soc
; 140(46): 15774-15782, 2018 11 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-30362749
3.
Halogen-Aromatic πâ Interactions Modulate Inhibitor Residence Times.
Angew Chem Int Ed Engl
; 57(24): 7220-7224, 2018 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-29601130
4.
Functional and Structural Characterization of Bub3·BubR1 Interactions Required for Spindle Assembly Checkpoint Signaling in Human Cells.
J Biol Chem
; 291(21): 11252-67, 2016 05 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-27030009
5.
BAY 1125976, a selective allosteric AKT1/2 inhibitor, exhibits high efficacy on AKT signaling-dependent tumor growth in mouse models.
Int J Cancer
; 140(2): 449-459, 2017 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27699769
6.
Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
J Biol Chem
; 289(13): 9304-19, 2014 Mar 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-24497639
7.
A universal homogeneous assay for high-throughput determination of binding kinetics.
Anal Biochem
; 468: 42-9, 2015 01 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-25240173
8.
A miniaturized mode-of-action profiling platform enables high throughput characterization of the molecular and cellular dynamics of EZH2 inhibition.
Sci Rep
; 14(1): 1739, 2024 01 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38242973
9.
Dual targeting of the androgen receptor and PI3K/AKT/mTOR pathways in prostate cancer models improves antitumor efficacy and promotes cell apoptosis.
Mol Oncol
; 18(3): 726-742, 2024 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-38225213
10.
Label-free high-throughput screening via acoustic ejection mass spectrometry put into practice.
SLAS Discov
; 28(5): 240-246, 2023 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-37031752
11.
Differential analyte derivatization enables unbiased MALDI-TOF-based high-throughput screening: A proof-of-concept study for the discovery of catechol-o-methyltransferase inhibitors.
SLAS Discov
; 27(5): 287-297, 2022 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-35597517
12.
Corrigendum to "A universal, homogenous assay for high throughput determination of binding kinetics" [Anal. Biochem. 468 (2015) 42-49].
Anal Biochem
; 514: 1, 2016 12 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27579818
13.
Acoustic Ejection Mass Spectrometry: A Fully Automatable Technology for High-Throughput Screening in Drug Discovery.
SLAS Discov
; 26(8): 961-973, 2021 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-34308708
14.
Characterization of the Menin-MLL Interaction as Therapeutic Cancer Target.
Cancers (Basel)
; 12(1)2020 Jan 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-31947537
15.
Discovery and Characterization of BAY 1214784, an Orally Available Spiroindoline Derivative Acting as a Potent and Selective Antagonist of the Human Gonadotropin-Releasing Hormone Receptor as Proven in a First-In-Human Study in Postmenopausal Women.
J Med Chem
; 63(20): 11854-11881, 2020 10 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-32960053
16.
Treating Cancer by Spindle Assembly Checkpoint Abrogation: Discovery of Two Clinical Candidates, BAY 1161909 and BAY 1217389, Targeting MPS1 Kinase.
J Med Chem
; 63(15): 8025-8042, 2020 08 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-32338514
17.
Identification and characterization of novel small molecules as potent inhibitors of the plasmodial calcium-dependent protein kinase 1.
Biochemistry
; 48(27): 6379-89, 2009 Jul 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-19507895
18.
Considerations for improved performance of competition association assays analysed with the Motulsky-Mahan's "kinetics of competitive binding" model.
Br J Pharmacol
; 176(24): 4731-4744, 2019 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31444916
19.
Probe dependency in the determination of ligand binding kinetics at a prototypical G protein-coupled receptor.
Sci Rep
; 9(1): 7906, 2019 05 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-31133718
20.
Inhibition of BUB1 Kinase by BAY 1816032 Sensitizes Tumor Cells toward Taxanes, ATR, and PARP Inhibitors In Vitro and In Vivo.
Clin Cancer Res
; 25(4): 1404-1414, 2019 02 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-30429199