Detalles de la búsqueda
1.
Cis-suppression to arrest protein aggregation in mammalian cells.
Biotechnol Bioeng
; 111(3): 462-74, 2014 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-24114411
2.
Distinct aggregation mechanisms of monoclonal antibody under thermal and freeze-thaw stresses revealed by hydrogen exchange.
Pharm Res
; 29(1): 236-50, 2012 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-21805212
3.
Computational design and biophysical characterization of aggregation-resistant point mutations for γD crystallin illustrate a balance of conformational stability and intrinsic aggregation propensity.
Biochemistry
; 50(5): 628-39, 2011 Feb 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-21184609
4.
Protein stability and structure in HIC: hydrogen exchange experiments and COREX calculations.
Langmuir
; 27(1): 286-95, 2011 Jan 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-21117672
5.
A new approach to explore the impact of freeze-thaw cycling on protein structure: hydrogen/deuterium exchange mass spectrometry (HX-MS).
Pharm Res
; 28(5): 1179-93, 2011 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-21301933
6.
Molecular level insights into thermally induced α-chymotrypsinogen A amyloid aggregation mechanism and semiflexible protofibril morphology.
Biochemistry
; 49(49): 10553-64, 2010 Dec 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-21067192
7.
Membrane interactions of a self-assembling model peptide that mimics the self-association, structure and toxicity of Abeta(1-40).
Biochim Biophys Acta
; 1788(9): 1714-21, 2009 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-19393615
8.
Structural differences between Abeta(1-40) intermediate oligomers and fibrils elucidated by proteolytic fragmentation and hydrogen/deuterium exchange.
Biophys J
; 96(3): 1091-104, 2009 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19186145
9.
Two disaccharides and trimethylamine N-oxide affect Abeta aggregation differently, but all attenuate oligomer-induced membrane permeability.
Biochemistry
; 48(37): 8908-19, 2009 Sep 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-19637920
10.
Structural understanding of stabilization patterns in engineered bispecific Ig-like antibody molecules.
Proteins
; 77(4): 832-41, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19626705
11.
Kinetic study of beta-amyloid residue accessibility using reductive alkylation and mass spectrometry.
Biotechnol Bioeng
; 104(1): 181-92, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19418563
12.
QCM-D sensitivity to protein adsorption reversibility.
Biotechnol Bioeng
; 101(4): 837-42, 2008 Nov 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-18623227
13.
Simultaneous monitoring of peptide aggregate distributions, structure, and kinetics using amide hydrogen exchange: application to Abeta(1-40) fibrillogenesis.
Biotechnol Bioeng
; 100(6): 1214-27, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18351682
14.
Advancement in the modeling of pressure-flow for the guidance of development and scale-up of commercial-scale biopharmaceutical chromatography.
J Chromatogr A
; 1190(1-2): 127-40, 2008 May 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-18374935
15.
Role of aggregation conditions in structure, stability, and toxicity of intermediates in the Abeta fibril formation pathway.
Protein Sci
; 16(4): 723-32, 2007 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-17327396
16.
Generalizing a two-conformation model for describing salt and temperature effects on protein retention and stability in hydrophobic interaction chromatography.
J Chromatogr A
; 1157(1-2): 197-206, 2007 Jul 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-17524412
17.
Loading, stationary phase, and salt effects during hydrophobic interaction chromatography: alpha-lactalbumin is stabilized at high loadings.
J Chromatogr A
; 1121(2): 209-18, 2006 Jul 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-16690064
18.
Simulation and experiment of temperature and cosolvent effects in reversed phase chromatography of peptides.
Biotechnol Prog
; 21(3): 893-6, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-15932270
19.
Structural features of interferon-gamma aggregation revealed by hydrogen exchange.
Protein Sci
; 11(6): 1340-52, 2002 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-12021433
20.
Aprotinin conformational distributions during reversed-phase liquid chromatography. Analysis by hydrogen-exchange mass spectrometry.
J Chromatogr A
; 1007(1-2): 55-66, 2003 Jul 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-12924551