Detalles de la búsqueda
1.
Use of extended-release and immediate-release anti-seizure medications with a long half-life to improve adherence in epilepsy: A guide for clinicians.
Epilepsy Behav
; 120: 107993, 2021 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-33971390
2.
Changes in perampanel levels during de-induction: Simulations following carbamazepine discontinuation.
Acta Neurol Scand
; 142(2): 131-138, 2020 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-32430908
3.
Pharmacokinetic/pharmacodynamic drug-drug interactions of avatrombopag when coadministered with dual or selective CYP2C9 and CYP3A interacting drugs.
Br J Clin Pharmacol
; 84(5): 952-960, 2018 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29341245
4.
Impact of perampanel on pharmacokinetics of concomitant antiepileptics in patients with partial-onset seizures: pooled analysis of clinical trials.
Br J Clin Pharmacol
; 82(2): 422-30, 2016 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-27038098
5.
The practical impact of altered dosing on perampanel plasma concentrations: pharmacokinetic modeling from clinical studies.
Epilepsy Behav
; 35: 6-12, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24785428
6.
Concentration-effect relationships with perampanel in patients with pharmacoresistant partial-onset seizures.
Epilepsia
; 54(8): 1490-7, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23772853
7.
Pharmacokinetics, Pharmacodynamics, and Safety of the Dual Orexin Receptor Antagonist Lemborexant: Findings From Single-Dose and Multiple-Ascending-Dose Phase 1 Studies in Healthy Adults.
Clin Pharmacol Drug Dev
; 10(2): 153-165, 2021 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-32468649
8.
Evaluation of the Effect of 5 QT-Positive Drugs on the JTpeak Interval - An Analysis of ECGs From the IQ-CSRC Study.
J Clin Pharmacol
; 60(1): 125-139, 2020 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-31378962
9.
Potential protein-binding displacement interactions with perampanel: An in vitro analysis.
Epilepsy Res
; 149: 102-106, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30580179
10.
Adjunctive Perampanel Oral Suspension in Pediatric Patients From ≥2 to <12 Years of Age With Epilepsy: Pharmacokinetics, Safety, Tolerability, and Efficacy.
J Child Neurol
; 34(5): 284-294, 2019 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-30739576
11.
Population Pharmacokinetic/Pharmacodynamic Analyses of Avatrombopag in Patients With Chronic Liver Disease and Optimal Dose Adjustment Guide With Concomitantly Administered CYP3A and CYP2C9 Inhibitors.
J Clin Pharmacol
; 58(12): 1629-1638, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-29905956
12.
Exposure-response analysis and simulation of lenvatinib safety and efficacy in patients with radioiodine-refractory differentiated thyroid cancer.
Cancer Chemother Pharmacol
; 82(6): 971-978, 2018 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-30244318
13.
Pharmacokinetics, Pharmacodynamics, Pharmacogenomics, Safety, and Tolerability of Avatrombopag in Healthy Japanese and White Subjects.
Clin Pharmacol Drug Dev
; 7(2): 188-195, 2018 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-28339166
14.
Effect of enzyme inhibition on perampanel pharmacokinetics: Why study design matters.
Epilepsy Res
; 134: 41-48, 2017 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-28535410
15.
Concentration-Response Modeling of ECG Data From Early-Phase Clinical Studies as an Alternative Clinical and Regulatory Approach to Assessing QT Risk - Experience From the Development Program of Lemborexant.
J Clin Pharmacol
; 57(1): 96-104, 2017 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-27338807
16.
Reducing placebo exposure in trials: Considerations from the Research Roundtable in Epilepsy.
Neurology
; 89(14): 1507-1515, 2017 Oct 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-28878049
17.
Single- and Multiple-dose Pharmacokinetics of a Lorcaserin Extended-release Tablet.
Clin Ther
; 38(10): 2227-2238.e4, 2016 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-27692638
18.
Pharmacokinetics, exposure-cognition, and exposure-efficacy relationships of perampanel in adolescents with inadequately controlled partial-onset seizures.
Epilepsy Res
; 127: 126-134, 2016 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-27595590
19.
Absence of Liver Toxicity in Perampanel-Treated Subjects: Pooled results from partial seizure phase III perampanel clinical studies.
Epilepsy Res
; 113: 76-85, 2015 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-25986193
20.
Lack of effect of perampanel on QT interval duration: Results from a thorough QT analysis and pooled partial seizure Phase III clinical trials.
Epilepsy Res
; 114: 122-30, 2015 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-26088895