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1.
Efficacy of selective histone deacetylase 6 inhibition in mouse models of Pseudomonas aeruginosa infection: A new glimpse for reducing inflammation and infection in cystic fibrosis.
Eur J Pharmacol
; 936: 175349, 2022 Dec 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-36309047
2.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclopropyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydroimid azo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 1.
Bioorg Med Chem Lett
; 21(15): 4422-8, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737272
3.
Identification of MK-5710 ((8aS)-8a-methyl-1,3-dioxo-2-[(1S,2R)-2-phenylcyclo- propyl]-N-(1-phenyl-1H-pyrazol-5-yl)hexahydro-imidazo[1,5-a]pyrazine-7(1H)-carboxamide), a potent smoothened antagonist for use in Hedgehog pathway dependent malignancies, part 2.
Bioorg Med Chem Lett
; 21(15): 4429-35, 2011 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-21737263
4.
MK-4101, a Potent Inhibitor of the Hedgehog Pathway, Is Highly Active against Medulloblastoma and Basal Cell Carcinoma.
Mol Cancer Ther
; 15(6): 1177-89, 2016 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-26960983
5.
Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells.
Oncotarget
; 4(8): 1280-92, 2013 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-23907569
6.
Smoothened antagonists: a promising new class of antitumor agents.
Expert Opin Drug Discov
; 4(5): 525-44, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-23485085
7.
Loss of histone deacetylase 4 causes segregation defects during mitosis of p53-deficient human tumor cells.
Cancer Res
; 69(15): 6074-82, 2009 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19622775
8.
Dissecting the biological functions of Drosophila histone deacetylases by RNA interference and transcriptional profiling.
J Biol Chem
; 281(26): 17968-76, 2006 Jun 30.
Artículo
en Inglés
| MEDLINE | ID: mdl-16632473
9.
The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus.
EMBO J
; 21(19): 5017-25, 2002 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12356718
10.
Crystal structure of a eukaryotic zinc-dependent histone deacetylase, human HDAC8, complexed with a hydroxamic acid inhibitor.
Proc Natl Acad Sci U S A
; 101(42): 15064-9, 2004 Oct 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-15477595
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