Detalles de la búsqueda
1.
Augmented Binary Substitution: Single-pass CDR germ-lining and stabilization of therapeutic antibodies.
Proc Natl Acad Sci U S A
; 112(50): 15354-9, 2015 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26621728
2.
A Combination of Structural and Empirical Analyses Delineates the Key Contacts Mediating Stability and Affinity Increases in an Optimized Biotherapeutic Single-chain Fv (scFv).
J Biol Chem
; 291(3): 1267-76, 2016 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-26515064
3.
Fundamental characteristics of the immunoglobulin VH repertoire of chickens in comparison with those of humans, mice, and camelids.
J Immunol
; 188(1): 322-33, 2012 Jan 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-22131336
4.
An ultra-specific avian antibody to phosphorylated tau protein reveals a unique mechanism for phosphoepitope recognition.
J Biol Chem
; 287(53): 44425-34, 2012 Dec 28.
Artículo
en Inglés
| MEDLINE | ID: mdl-23148212
5.
A high-affinity recombinant antibody permits rapid and sensitive direct detection of myeloperoxidase.
Anal Biochem
; 410(1): 1-6, 2011 Mar 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20920456
6.
Polyreactivity and polyspecificity in therapeutic antibody development: risk factors for failure in preclinical and clinical development campaigns.
MAbs
; 13(1): 1999195, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34780320
7.
De novo discovery of antibody drugs - great promise demands scrutiny.
MAbs
; 11(5): 809-811, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31122133
8.
Anti-PD1 'SHR-1210' aberrantly targets pro-angiogenic receptors and this polyspecificity can be ablated by paratope refinement.
MAbs
; 11(1): 26-44, 2019 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-30541416
9.
Establishing in vitro in vivo correlations to screen monoclonal antibodies for physicochemical properties related to favorable human pharmacokinetics.
MAbs
; 10(2): 244-255, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29271699
10.
Optimized Generation of High-Affinity, High-Specificity Single-Chain Fv Antibodies from Multi-Antigen Immunized Chickens.
Methods Mol Biol
; 1485: 319-338, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27730560
11.
Phage Display: A Powerful Technology for the Generation of High-Specificity Affinity Reagents from Alternative Immune Sources.
Methods Mol Biol
; 1485: 85-99, 2017.
Artículo
en Inglés
| MEDLINE | ID: mdl-27730550
12.
Development of PF-06671008, a Highly Potent Anti-P-cadherin/Anti-CD3 Bispecific DART Molecule with Extended Half-Life for the Treatment of Cancer.
Antibodies (Basel)
; 5(1)2016 Mar 04.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557987
13.
Comprehensive interrogation of a minimalist synthetic CDR-H3 library and its ability to generate antibodies with therapeutic potential.
J Mol Biol
; 425(10): 1712-30, 2013 May 27.
Artículo
en Inglés
| MEDLINE | ID: mdl-23429058
14.
CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
MAbs
; 5(6): 882-95, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23995618
15.
Natural and man-made V-gene repertoires for antibody discovery.
Front Immunol
; 3: 342, 2012.
Artículo
en Inglés
| MEDLINE | ID: mdl-23162556
16.
Phage display: a powerful technology for the generation of high specificity affinity reagents from alternative immune sources.
Methods Mol Biol
; 681: 87-101, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-20978962
17.
Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens.
Methods Mol Biol
; 681: 383-401, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-20978977
18.
Developing cell-specific antibodies to endothelial progenitor cells using avian immune phage display technology.
J Biomol Screen
; 16(7): 744-54, 2011 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-21593485
19.
Synthetic antibodies designed on natural sequence landscapes.
J Mol Biol
; 412(1): 55-71, 2011 Sep 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-21787786
20.
Affinity maturation of a humanized rat antibody for anti-RAGE therapy: comprehensive mutagenesis reveals a high level of mutational plasticity both inside and outside the complementarity-determining regions.
J Mol Biol
; 388(3): 541-58, 2009 May 08.
Artículo
en Inglés
| MEDLINE | ID: mdl-19285987