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1.
The Role of Cholesterol on Triterpenoid Saponin-Induced Endolysosomal Escape of a Saporin-Based Immunotoxin.
Int J Mol Sci
; 21(22)2020 Nov 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-33228031
2.
Antibody-Drug Conjugates: The New Frontier of Chemotherapy.
Int J Mol Sci
; 21(15)2020 Jul 31.
Artículo
en Inglés
| MEDLINE | ID: mdl-32752132
3.
A Flow Cytometric Method to Quantify the Endosomal Escape of a Protein Toxin to the Cytosol of Target Cells.
Pharm Res
; 37(1): 16, 2019 Dec 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-31873810
4.
Membrane cholesterol is essential for triterpenoid saponin augmentation of a saporin-based immunotoxin directed against CD19 on human lymphoma cells.
Biochim Biophys Acta Biomembr
; 1859(5): 993-1007, 2017 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-28235471
5.
Optimization of construct design and fermentation strategy for the production of bioactive ATF-SAP, a saporin based anti-tumoral uPAR-targeted chimera.
Microb Cell Fact
; 15(1): 194, 2016 Nov 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-27842546
6.
Systematic comparison of single-chain Fv antibody-fusion toxin constructs containing Pseudomonas Exotoxin A or saporin produced in different microbial expression systems.
Microb Cell Fact
; 14: 19, 2015 Feb 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-25889802
7.
Triterpenoid saponin augmention of saporin-based immunotoxin cytotoxicity for human leukaemia and lymphoma cells is partially immunospecific and target molecule dependent.
Immunopharmacol Immunotoxicol
; 37(1): 42-55, 2015 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-25347443
8.
Plant-Derived Type I Ribosome Inactivating Protein-Based Targeted Toxins: A Review of the Clinical Experience.
Toxins (Basel)
; 14(8)2022 08 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-36006226
9.
Countering immunotoxin immunogenicity.
Br J Cancer
; 114(11): 1177-9, 2016 05 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-27219287
10.
Pichia pastoris as a host for secretion of toxic saporin chimeras.
FASEB J
; 24(1): 253-65, 2010 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-19786581
11.
The Effect of Small Molecule Pharmacological Agents on the Triterpenoid Saponin Induced Endolysosomal Escape of Saporin and a Saporin-Based Immunotoxin in Target Human Lymphoma Cells.
Biomedicines
; 9(3)2021 Mar 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-33804080
12.
The TLR3 Agonist Poly Inosinic:Cytidylic Acid Significantly Augments the Therapeutic Activity of an Anti-CD7 Immunotoxin for Human T-cell Leukaemia.
Biomedicines
; 7(1)2019 Feb 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30781517
13.
Augmentation of Saporin-Based Immunotoxins for Human Leukaemia and Lymphoma Cells by Triterpenoid Saponins: The Modifying Effects of Small Molecule Pharmacological Agents.
Toxins (Basel)
; 11(2)2019 02 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-30791598
14.
Strategies to Improve the Clinical Utility of Saporin-Based Targeted Toxins.
Toxins (Basel)
; 10(2)2018 02 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-29438358
15.
Saporin and ricin A chain follow different intracellular routes to enter the cytosol of intoxicated cells.
FEBS J
; 272(19): 4983-95, 2005 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-16176271
16.
European Clinical Trials Directive: responses made to MHRA consultation letter MLX 287.
Lancet
; 362(9393): 1415, 2003 Oct 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-14585646
17.
Engineering a switchable toxin: the potential use of PDZ domains in the expression, targeting and activation of modified saporin variants.
Protein Eng Des Sel
; 23(2): 61-8, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19933699
18.
The anti-CD20 antibody rituximab augments the immunospecific therapeutic effectiveness of an anti-CD19 immunotoxin directed against human B-cell lymphoma.
Br J Haematol
; 134(2): 157-70, 2006 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-16771848
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