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1.
Bench-top to clinical therapies: A review of melanocortin ligands from 1954 to 2016.
Biochim Biophys Acta Mol Basis Dis
; 1863(10 Pt A): 2414-2435, 2017 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-28363699
2.
Comparative Intracerebroventricular and Intrathecal Administration of a Nanomolar Macrocyclic Melanocortin Receptor Agonist MDE6-5-2c (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro]) Decreases Food Intake in Mice.
ACS Chem Neurosci
; 11(19): 3051-3063, 2020 10 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-32822157
3.
Discovery of Polypharmacological Melanocortin-3 and -4 Receptor Probes and Identification of a 100-Fold Selective nM MC3R Agonist versus a µM MC4R Partial Agonist.
J Med Chem
; 62(5): 2738-2749, 2019 03 14.
Artículo
en Inglés
| MEDLINE | ID: mdl-30741545
4.
Synergistic Multiresidue Substitutions of a Macrocyclic c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-dPro] Agouti-Related Protein (AGRP) Scaffold Yield Potent and >600-Fold MC4R versus MC3R Selective Melanocortin Receptor Antagonists.
J Med Chem
; 61(17): 7729-7740, 2018 09 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-30035543
5.
Arg-Phe-Phe d-Amino Acid Stereochemistry Scan in the Macrocyclic Agouti-Related Protein Antagonist Scaffold c[Pro-Arg-Phe-Phe-Xxx-Ala-Phe-DPro] Results in Unanticipated Melanocortin-1 Receptor Agonist Profiles.
ACS Chem Neurosci
; 9(12): 3015-3023, 2018 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-29924583
6.
Structure-Activity Relationship Studies of a Macrocyclic AGRP-Mimetic Scaffold c[Pro-Arg-Phe-Phe-Asn-Ala-Phe-DPro] Yield Potent and Selective Melanocortin-4 Receptor Antagonists and Melanocortin-5 Receptor Inverse Agonists That Increase Food Intake in Mice.
ACS Chem Neurosci
; 9(5): 1141-1151, 2018 05 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-29363944
7.
Structure-Activity Relationship Studies on a Macrocyclic Agouti-Related Protein (AGRP) Scaffold Reveal Agouti Signaling Protein (ASP) Residue Substitutions Maintain Melanocortin-4 Receptor Antagonist Potency and Result in Inverse Agonist Pharmacology at the Melanocortin-5 Receptor.
J Med Chem
; 60(19): 8103-8114, 2017 10 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-28813605
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