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1.
Low-molecular weight inhibitors of the alternative complement pathway.
Immunol Rev
; 313(1): 339-357, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36217774
2.
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc Natl Acad Sci U S A
; 116(16): 7926-7931, 2019 04 16.
Artículo
en Inglés
| MEDLINE | ID: mdl-30926668
3.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Nat Chem Biol
; 12(12): 1105-1110, 2016 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-27775713
4.
Plasma contact system activation drives anaphylaxis in severe mast cell-mediated allergic reactions.
J Allergy Clin Immunol
; 135(4): 1031-1043.e6, 2015 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-25240785
5.
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV.
Bioorg Med Chem Lett
; 24(3): 731-6, 2014 Feb 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-24439847
6.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
J Med Chem
; 63(11): 5697-5722, 2020 06 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-32073845
7.
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
J Med Chem
; 62(9): 4656-4668, 2019 05 09.
Artículo
en Inglés
| MEDLINE | ID: mdl-30995036
8.
Discovery of Highly Potent and Selective Small-Molecule Reversible Factor D Inhibitors Demonstrating Alternative Complement Pathway Inhibition in Vivo.
J Med Chem
; 60(13): 5717-5735, 2017 07 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-28621538
9.
Identification of nonpeptidic urotensin II receptor antagonists by virtual screening based on a pharmacophore model derived from structure-activity relationships and nuclear magnetic resonance studies on urotensin II.
J Med Chem
; 45(9): 1799-805, 2002 Apr 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-11960491
10.
Functional and binding characterizations of urotensin II-related peptides in human and rat urotensin II-receptor assay.
J Pharmacol Exp Ther
; 306(3): 1200-9, 2003 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-12807997
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