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1.
An Industry Survey With Focus on Cardiovascular Safety Pharmacology Study Design and Data Interpretation.
Int J Toxicol
; 39(4): 274-293, 2020.
Artículo
en Inglés
| MEDLINE | ID: mdl-32406289
2.
Preclinical cardiovascular safety assessment of pharmacology-toxicology relationship for a set of novel kinase inhibitors.
Toxicol Sci
; 198(2): 316-327, 2024 Mar 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-38191231
3.
Evaluation of the translation of multiple cardiovascular regulatory mechanisms in the anesthetized dog.
J Pharmacol Toxicol Methods
; 126: 107497, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38479593
4.
Development of a pharmaceutical database as an aid to the nonclinical detection of drug-induced cardiac toxicity.
J Pharmacol Toxicol Methods
; 127: 107507, 2024.
Artículo
en Inglés
| MEDLINE | ID: mdl-38636673
5.
Safety pharmacology 2023 and implementation of the ICH E14/S7B Q&A guidance document.
J Pharmacol Toxicol Methods
; 123: 107300, 2023.
Artículo
en Inglés
| MEDLINE | ID: mdl-37524151
6.
A method for assessing and monitoring consistency of nonclinical ECG analysis.
J Pharmacol Toxicol Methods
; 116: 107189, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35688321
7.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 109: 107066, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-33838254
8.
Automated Blood Sampling in a Canine Telemetry Cardiovascular Model.
Comp Med
; 71(2): 133-140, 2021 04 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-33814031
9.
Automated blood sampling in canine telemetry studies: Enabling enhanced assessments of cardiovascular liabilities and safety margins.
J Pharmacol Toxicol Methods
; 111: 107109, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34416395
10.
Automated blood sampling in canine telemetry model: Enhanced assessment of immune liabilities.
J Pharmacol Toxicol Methods
; 112: 107115, 2021.
Artículo
en Inglés
| MEDLINE | ID: mdl-34403748
11.
Improving the in vivo QTc assay: Nonclinical concentration-QTc modeling for risk assessment.
J Pharmacol Toxicol Methods
; 128: 107515, 2024 May 20.
Artículo
en Inglés
| MEDLINE | ID: mdl-38777240
12.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Adverse Drug-Induced Inotropic Effects in Early Drug Development. Part 1: General Considerations for Development of Novel Testing Platforms.
Front Pharmacol
; 10: 884, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31447679
13.
Considerations for an In Vitro, Cell-Based Testing Platform for Detection of Drug-Induced Inotropic Effects in Early Drug Development. Part 2: Designing and Fabricating Microsystems for Assaying Cardiac Contractility With Physiological Relevance Using Human iPSC-Cardiomyocytes.
Front Pharmacol
; 10: 934, 2019.
Artículo
en Inglés
| MEDLINE | ID: mdl-31555128
14.
The evaluation of endpoint variability and implications for study statistical power and sample size in conscious instrumented dogs.
J Pharmacol Toxicol Methods
; 92: 43-51, 2018.
Artículo
en Inglés
| MEDLINE | ID: mdl-29505899
15.
Multipotent adult progenitor cell lines originating from the peripheral blood of green fluorescent protein transgenic swine.
Stem Cells Dev
; 15(4): 507-22, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16978055
16.
Increased nitric oxide synthase activity and expression in the hypothalamus of hindlimb unloaded rats.
Brain Res
; 1115(1): 65-74, 2006 Oct 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-16938283
17.
Immunohistochemical localization of GAD67-expressing neurons and processes in the rat brainstem: subregional distribution in the nucleus tractus solitarius.
J Comp Neurol
; 493(2): 274-90, 2005 Dec 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-16255028
18.
Evaluation of cardiovascular changes in dogs administered three positive controls using jacketed external telemetry-blood pressure (JET-BP).
J Pharmacol Toxicol Methods
; 75: 27-37, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26001324
19.
GABA(A) alpha1 and alpha2 receptor subunit expression in rostral ventrolateral medulla in nonpregnant and pregnant rats.
Brain Res
; 975(1-2): 196-206, 2003 Jun 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-12763608
20.
Intravenous solid tip ECG lead placement in telemetry implanted dogs: Part 2: High quality telemetry signals yield high sensitivity to drug-induced changes.
J Pharmacol Toxicol Methods
; 68(1): 62-73, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-23639348