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1.
The acyclic CB1R inverse agonist taranabant mediates weight loss by increasing energy expenditure and decreasing caloric intake.
Cell Metab
; 7(1): 68-78, 2008 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-18177726
2.
Efficacy and Safety of 0.01% and 0.02% Atropine for the Treatment of Pediatric Myopia Progression Over 3 Years: A Randomized Clinical Trial.
JAMA Ophthalmol
; 141(10): 990-999, 2023 Oct 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37261839
3.
Neuronal activation in the hypothalamus and brainstem during feeding in rats.
Cell Metab
; 4(4): 313-21, 2006 Oct.
Artículo
en Inglés
| MEDLINE | ID: mdl-17011504
4.
MK-7128, a novel CB1 receptor inverse agonist, improves scopolamine-induced learning and memory deficits in mice.
Behav Pharmacol
; 22(2): 91-100, 2011 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-21301326
5.
Discovery of a piperazine urea based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor partial agonist.
Bioorg Med Chem Lett
; 21(8): 2330-4, 2011 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21439820
6.
Genome-wide expression profiling revealed peripheral effects of cannabinoid receptor 1 inverse agonists in improving insulin sensitivity and metabolic parameters.
Mol Pharmacol
; 78(3): 350-9, 2010 Sep.
Artículo
en Inglés
| MEDLINE | ID: mdl-20530130
7.
Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant.
Bioorg Med Chem Lett
; 20(16): 4757-61, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20643546
8.
Dihydro-pyrano[2,3-b]pyridines and tetrahydro-1,8-naphthyridines as CB1 receptor inverse agonists: synthesis, SAR and biological evaluation.
Bioorg Med Chem Lett
; 20(12): 3750-4, 2010 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20483606
9.
Furo[2,3-b]pyridine-based cannabinoid-1 receptor inverse agonists: synthesis and biological evaluation. Part 1.
Bioorg Med Chem Lett
; 20(4): 1448-52, 2010 Feb 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20096577
10.
Optimization of privileged structures for selective and potent melanocortin subtype-4 receptor ligands.
Bioorg Med Chem Lett
; 20(15): 4483-6, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598533
11.
Discovery of potent, selective, and orally bioavailable 3H-spiro[isobenzofuran-1,4'-piperidine] based melanocortin subtype-4 receptor agonists.
Bioorg Med Chem Lett
; 20(16): 4895-900, 2010 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20621473
12.
Discovery of highly potent and efficacious MC4R agonists with spiroindane N-Me-1,2,4-triazole privileged structures for the treatment of obesity.
Bioorg Med Chem Lett
; 20(22): 6524-32, 2010 Nov 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-20933410
13.
Discovery of a spiroindane based compound as a potent, selective, orally bioavailable melanocortin subtype-4 receptor agonist.
Bioorg Med Chem Lett
; 20(7): 2106-10, 2010 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20207541
14.
Spiroindane based amides as potent and selective MC4R agonists for the treatment of obesity.
Bioorg Med Chem Lett
; 20(15): 4399-405, 2010 Aug 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20598882
15.
Synthesis and evaluation of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-aminopropanamide as human cannabinoid-1 receptor (CB1R) inverse agonists.
Bioorg Med Chem Lett
; 19(17): 5195-9, 2009 Sep 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19632830
16.
Pyridopyrimidine based cannabinoid-1 receptor inverse agonists: Synthesis and biological evaluation.
Bioorg Med Chem Lett
; 19(9): 2591-4, 2009 May 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-19328684
17.
The triple uptake inhibitor (1R,5S)-(+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0] hexane hydrochloride (DOV 21947) reduces body weight and plasma triglycerides in rodent models of diet-induced obesity.
J Pharmacol Exp Ther
; 324(3): 1111-26, 2008 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-18089843
18.
Conformational analysis and receptor docking of N-[(1S,2S)-3-(4-chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2-{[5-(trifluoromethyl)pyridin-2-yl]oxy}propanamide (taranabant, MK-0364), a novel, acyclic cannabinoid-1 receptor inverse agonist.
J Med Chem
; 51(7): 2108-14, 2008 Apr 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18333607
19.
Cyclic analogs of alpha-melanocyte-stimulating hormone (alphaMSH) with high agonist potency and selectivity at human melanocortin receptor 1b.
Peptides
; 29(6): 1010-7, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18378043
20.
GABAB receptors are required for galanin modulation of membrane properties of neurons in the arcuate nucleus of rats.
Brain Res
; 1191: 63-8, 2008 Jan 29.
Artículo
en Inglés
| MEDLINE | ID: mdl-18096145