Detalles de la búsqueda
1.
Acute hemodynamic and renal effects of glucagon-like peptide 1 analog and dipeptidyl peptidase-4 inhibitor in rats.
Cardiovasc Diabetol
; 14: 29, 2015 Mar 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-25888997
2.
A potent and selective indole N-type calcium channel (Ca(v)2.2) blocker for the treatment of pain.
Bioorg Med Chem Lett
; 21(2): 869-73, 2011 Jan 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-21195616
3.
Chronic antagonism of the mineralocorticoid receptor ameliorates hypertension and end organ damage in a rodent model of salt-sensitive hypertension.
Clin Exp Hypertens
; 33(8): 538-47, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21950654
4.
Discovery of betamethasone 17alpha-carbamates as dissociated glucocorticoid receptor modulators in the rat.
Bioorg Med Chem
; 16(16): 7535-42, 2008 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-18691892
5.
Discovery of biaryl anthranilides as full agonists for the high affinity niacin receptor.
J Med Chem
; 50(25): 6303-6, 2007 Dec 13.
Artículo
en Inglés
| MEDLINE | ID: mdl-17994679
6.
Comparison of rat and dog models of vasodilatation and lipolysis for the calculation of a therapeutic index for GPR109A agonists.
J Pharmacol Toxicol Methods
; 56(3): 308-16, 2007.
Artículo
en Inglés
| MEDLINE | ID: mdl-17643322
7.
Chronic Inhibition of Renal Outer Medullary Potassium Channel Not Only Prevented but Also Reversed Development of Hypertension and End-Organ Damage in Dahl Salt-Sensitive Rats.
Hypertension
; 69(2): 332-338, 2017 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-27920129
8.
Discovery of a novel series of peroxisome proliferator-activated receptor alpha/gamma dual agonists for the treatment of type 2 diabetes and dyslipidemia.
J Med Chem
; 48(7): 2262-5, 2005 Apr 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-15801817
9.
Novel N-arylpyrazolo[3,2-c]-based ligands for the glucocorticoid receptor: receptor binding and in vivo activity.
J Med Chem
; 47(10): 2441-52, 2004 May 06.
Artículo
en Inglés
| MEDLINE | ID: mdl-15115388
10.
Skeletal muscle: a dual system to measure glucocorticoid-dependent transactivation and transrepression of gene regulation.
J Steroid Biochem Mol Biol
; 88(2): 191-201, 2004 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-15084351
11.
Comparison of Cardiovascular Parameters and/or Serum Chemistry and Hematology Profiles in Conscious and Anesthetized Rhesus Monkeys (Macaca mulatta).
Contemp Top Lab Anim Sci
; 38(2): 60-64, 1999 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-12086436
12.
On- and off-target pharmacology of torcetrapib: current understanding and implications for the structure activity relationships (SAR), discovery and development of cholesteryl ester-transfer protein (CETP) inhibitors.
Drugs
; 72(4): 491-507, 2012 Mar 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-22356288
13.
Discovery of a biaryl cyclohexene carboxylic acid (MK-6892): a potent and selective high affinity niacin receptor full agonist with reduced flushing profiles in animals as a preclinical candidate.
J Med Chem
; 53(6): 2666-70, 2010 Mar 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-20184326
14.
A novel 3-dimensional micro-ultrasound approach to automated measurement of carotid arterial plaque volume as a biomarker for experimental atherosclerosis.
Atherosclerosis
; 204(1): 55-65, 2009 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-19135672
15.
Novel glucocorticoids containing a 6,5-bicyclic core fused to a pyrazole ring: synthesis, in vitro profile, molecular modeling studies, and in vivo experiments.
Bioorg Med Chem Lett
; 17(12): 3354-61, 2007 Jun 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-17467988
16.
Sphingosine-1-phosphate agonists increase macrophage homing, lymphocyte contacts, and endothelial junctional complex formation in murine lymph nodes.
J Immunol
; 175(11): 7151-61, 2005 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-16301618
17.
Novel heterocyclic glucocorticoids: in vitro profile and in vivo efficacy.
Bioorg Med Chem Lett
; 15(8): 2163-7, 2005 Apr 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-15808489
18.
Novel ketal ligands for the glucocorticoid receptor: in vitro and in vivo activity.
Bioorg Med Chem Lett
; 15(11): 2926-31, 2005 Jun 02.
Artículo
en Inglés
| MEDLINE | ID: mdl-15911283
19.
Sphingosine-1-phosphate receptor agonism impairs the efficiency of the local immune response by altering trafficking of naive and antigen-activated CD4+ T cells.
J Immunol
; 170(7): 3662-70, 2003 Apr 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-12646631
20.
Impaired neuropathic pain responses in mice lacking the chemokine receptor CCR2.
Proc Natl Acad Sci U S A
; 100(13): 7947-52, 2003 Jun 24.
Artículo
en Inglés
| MEDLINE | ID: mdl-12808141