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1.
Difluoromethyl-1,3,4-oxadiazoles are slow-binding substrate analog inhibitors of histone deacetylase 6 with unprecedented isotype selectivity.
J Biol Chem
; 299(1): 102800, 2023 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-36528061
2.
Improved In Vivo Anti-Tumor and Anti-Metastatic Effect of GnRH-III-Daunorubicin Analogs on Colorectal and Breast Carcinoma Bearing Mice.
Int J Mol Sci
; 20(19)2019 Sep 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-31557968
3.
Histone deacetylase 3 regulates the inflammatory gene expression programme of rheumatoid arthritis fibroblast-like synoviocytes.
Ann Rheum Dis
; 76(1): 277-285, 2017 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-27457515
4.
Lysine deacetylase inhibition prevents diabetes by chromatin-independent immunoregulation and ß-cell protection.
Proc Natl Acad Sci U S A
; 111(3): 1055-9, 2014 Jan 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-24395784
5.
Specific inhibition of histone deacetylase 8 reduces gene expression and production of proinflammatory cytokines in vitro and in vivo.
J Biol Chem
; 290(4): 2368-78, 2015 Jan 23.
Artículo
en Inglés
| MEDLINE | ID: mdl-25451941
6.
Suppression of monosodium urate crystal-induced cytokine production by butyrate is mediated by the inhibition of class I histone deacetylases.
Ann Rheum Dis
; 75(3): 593-600, 2016 Mar.
Artículo
en Inglés
| MEDLINE | ID: mdl-25589513
7.
Modulation of gamma globin genes expression by histone deacetylase inhibitors: an in vitro study.
Br J Haematol
; 165(5): 714-21, 2014 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-24606390
8.
LKB1 signaling is altered in skeletal muscle of a Duchenne muscular dystrophy mouse model.
Dis Model Mech
; 16(7)2023 07 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-37427454
9.
The Importance of the "Time Factor" for the Evaluation of Inhibition Mechanisms: The Case of Selected HDAC6 Inhibitors.
Biology (Basel)
; 12(8)2023 Jul 26.
Artículo
en Inglés
| MEDLINE | ID: mdl-37626935
10.
Inhibition of the lysine demethylase LSD1 modulates the balance between inflammatory and antiviral responses against coronaviruses.
Sci Signal
; 16(816): eade0326, 2023 12 19.
Artículo
en Inglés
| MEDLINE | ID: mdl-38113337
11.
Epigenetic-based cancer therapeutics: new potential HDAC8 inhibitors.
J Biomol Struct Dyn
; 40(1): 297-311, 2022 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-32886033
12.
HDAC Inhibition as Potential Therapeutic Strategy to Restore the Deregulated Immune Response in Severe COVID-19.
Front Immunol
; 13: 841716, 2022.
Artículo
en Inglés
| MEDLINE | ID: mdl-35592335
13.
Histone deacetylase inhibitors for treating a spectrum of diseases not related to cancer.
Mol Med
; 17(5-6): 333-52, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21556484
14.
Pharmacokinetics, safety and inducible cytokine responses during a phase 1 trial of the oral histone deacetylase inhibitor ITF2357 (givinostat).
Mol Med
; 17(5-6): 353-62, 2011.
Artículo
en Inglés
| MEDLINE | ID: mdl-21365126
15.
ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way.
Proc Natl Acad Sci U S A
; 105(23): 8067-72, 2008 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-18523012
16.
The pan HDAC inhibitor Givinostat improves muscle function and histological parameters in two Duchenne muscular dystrophy murine models expressing different haplotypes of the LTBP4 gene.
Skelet Muscle
; 11(1): 19, 2021 07 22.
Artículo
en Inglés
| MEDLINE | ID: mdl-34294164
17.
Role of Fluorination in the Histone Deacetylase 6 (HDAC6) Selectivity of Benzohydroxamate-Based Inhibitors.
ACS Med Chem Lett
; 12(11): 1810-1817, 2021 Nov 11.
Artículo
en Inglés
| MEDLINE | ID: mdl-34795871
18.
Pleiotropic anti-myeloma activity of ITF2357: inhibition of interleukin-6 receptor signaling and repression of miR-19a and miR-19b.
Haematologica
; 95(2): 260-9, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19713220
19.
Histone deacetylase (HDAC) inhibitors reduce the glial inflammatory response in vitro and in vivo.
Neurobiol Dis
; 36(2): 269-79, 2009 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-19635561
20.
Novel Benzohydroxamate-Based Potent and Selective Histone Deacetylase 6 (HDAC6) Inhibitors Bearing a Pentaheterocyclic Scaffold: Design, Synthesis, and Biological Evaluation.
J Med Chem
; 62(23): 10711-10739, 2019 12 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-31710483