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1.
Structure-based design, synthesis and A-site rRNA co-crystal complexes of novel amphiphilic aminoglycoside antibiotics with new binding modes: a synergistic hydrophobic effect against resistant bacteria.
Bioorg Med Chem Lett
; 20(23): 7097-101, 2010 Dec 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-20970332
2.
Structure-based design, synthesis, and A-site rRNA cocrystal complexes of functionally novel aminoglycoside antibiotics: C2" ether analogues of paromomycin.
J Med Chem
; 50(10): 2352-69, 2007 May 17.
Artículo
en Inglés
| MEDLINE | ID: mdl-17458946
3.
Crystal structures of complexes between aminoglycosides and decoding A site oligonucleotides: role of the number of rings and positive charges in the specific binding leading to miscoding.
Nucleic Acids Res
; 33(17): 5677-90, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-16214802
4.
Crystal structure of the bacterial ribosomal decoding site complexed with amikacin containing the gamma-amino-alpha-hydroxybutyryl (haba) group.
Biochimie
; 88(8): 1027-31, 2006 Aug.
Artículo
en Inglés
| MEDLINE | ID: mdl-16806634
5.
Crystal structure of the Homo sapiens cytoplasmic ribosomal decoding site complexed with apramycin.
Angew Chem Int Ed Engl
; 45(20): 3310-4, 2006 May 12.
Artículo
en Inglés
| MEDLINE | ID: mdl-16596680
6.
Antibacterial aminoglycosides with a modified mode of binding to the ribosomal-RNA decoding site.
Angew Chem Int Ed Engl
; 43(48): 6735-8, 2004 Dec 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-15593140
7.
Crystal structure of the bacterial ribosomal decoding site complexed with a synthetic doubly functionalized paromomycin derivative: a new specific binding mode to an a-minor motif enhances in vitro antibacterial activity.
ChemMedChem
; 2(11): 1631-8, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17722211
8.
Binding of neomycin-class aminoglycoside antibiotics to mutant ribosomes with alterations in the A site of 16S rRNA.
Antimicrob Agents Chemother
; 50(4): 1489-96, 2006 Apr.
Artículo
en Inglés
| MEDLINE | ID: mdl-16569869
9.
Crystallographic studies of Homo sapiens ribosomal decoding A site complexed with aminoglycosides.
Nucleic Acids Symp Ser (Oxf)
; (49): 253-4, 2005.
Artículo
en Inglés
| MEDLINE | ID: mdl-17150729
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