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1.
Indinavir Increases Midazolam N-Glucuronidation in Humans: Identification of an Alternate CYP3A Inhibitor Using an In Vitro to In Vivo Approach.
Drug Metab Dispos
; 47(7): 724-731, 2019 07.
Artículo
en Inglés
| MEDLINE | ID: mdl-31028057
2.
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Bioorg Med Chem Lett
; 28(5): 979-984, 2018 03 01.
Artículo
en Inglés
| MEDLINE | ID: mdl-29254646
3.
Identification of a novel, non-tetrahydroquinoline variant of the cholesteryl ester transfer protein (CETP) inhibitor torcetrapib, with improved aqueous solubility.
Xenobiotica
; 44(7): 591-605, 2014 Jul.
Artículo
en Inglés
| MEDLINE | ID: mdl-24380613
4.
Elucidation of the biochemical basis for a clinical drug-drug interaction between atorvastatin and 5-(N-(4-((4-ethylbenzyl)thio)phenyl)sulfamoyl)-2-methyl benzoic acid (CP-778875), a subtype selective agonist of the peroxisome proliferator-activated receptor alpha.
Xenobiotica
; 43(11): 963-72, 2013 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-23631744
5.
Identification of novel series of pyrazole and indole-urea based DFG-out PYK2 inhibitors.
Bioorg Med Chem Lett
; 22(24): 7523-9, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-23153798
6.
Discovery tactics to mitigate toxicity risks due to reactive metabolite formation with 2-(2-hydroxyaryl)-5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3h)-one derivatives, potent calcium-sensing receptor antagonists and clinical candidate(s) for the treatment of osteoporosis.
Chem Res Toxicol
; 23(6): 1115-26, 2010 Jun 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-20507089
7.
Short-acting 5-(trifluoromethyl)pyrido[4,3-d]pyrimidin-4(3H)-one derivatives as orally-active calcium-sensing receptor antagonists.
Bioorg Med Chem Lett
; 19(16): 4555-9, 2009 Aug 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-19625189
8.
Comparison of the bioactivation potential of the antidepressant and hepatotoxin nefazodone with aripiprazole, a structural analog and marketed drug.
Drug Metab Dispos
; 36(6): 1016-29, 2008 Jun.
Artículo
en Inglés
| MEDLINE | ID: mdl-18332080
9.
CCR2 receptor blockade alters blood monocyte subpopulations but does not affect atherosclerotic lesions in apoE(-/-) mice.
Atherosclerosis
; 208(2): 370-5, 2010 Feb.
Artículo
en Inglés
| MEDLINE | ID: mdl-19837409
10.
N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
J Pharm Sci
; 98(12): 4914-27, 2009 Dec.
Artículo
en Inglés
| MEDLINE | ID: mdl-19373887
11.
NADPH-dependent covalent binding of [3H]paroxetine to human liver microsomes and S-9 fractions: identification of an electrophilic quinone metabolite of paroxetine.
Chem Res Toxicol
; 20(11): 1649-57, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17907785
12.
Role of transporters in the disposition of the selective phosphodiesterase-4 inhibitor (+)-2-[4-({[2-(benzo[1,3]dioxol-5-yloxy)-pyridine-3-carbonyl]-amino}-methyl)-3-fluoro-phenoxy]-propionic acid in rat and human.
Drug Metab Dispos
; 35(11): 2111-8, 2007 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-17686907
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