Detalles de la búsqueda
1.
The Histone Deacetylase Inhibitor Valproic Acid Exerts a Synergistic Cytotoxicity with the DNA-Damaging Drug Ellipticine in Neuroblastoma Cells.
Int J Mol Sci
; 19(1)2018 Jan 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-29304031
2.
NADH:Cytochrome b5 Reductase and Cytochrome b5 Can Act as Sole Electron Donors to Human Cytochrome P450 1A1-Mediated Oxidation and DNA Adduct Formation by Benzo[a]pyrene.
Chem Res Toxicol
; 29(8): 1325-34, 2016 08 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-27404282
3.
Effectiveness of human cytochrome P450 3A4 present in liposomal and microsomal nanoparticles in formation of covalent DNA adducts by ellipticine.
Neuro Endocrinol Lett
; 37(Suppl1): 95-102, 2016 Dec 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-28263536
4.
Active Site Mutations as a Suitable Tool Contributing to Explain a Mechanism of Aristolochic Acid I Nitroreduction by Cytochromes P450 1A1, 1A2 and 1B1.
Int J Mol Sci
; 17(2): 213, 2016 Feb 05.
Artículo
en Inglés
| MEDLINE | ID: mdl-26861298
5.
Biotransformation of xenobiotics in the human colon and rectum and its association with colorectal cancer.
Drug Metab Rev
; 47(2): 199-221, 2015 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-25686853
6.
The influence of ochratoxin A on DNA adduct formation by the carcinogen aristolochic acid in rats.
Arch Toxicol
; 89(11): 2141-58, 2015 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-25209566
7.
Cytotoxicity of and DNA adduct formation by ellipticine and its micellar form in human leukemia cells in vitro.
Neuro Endocrinol Lett
; 36 Suppl 1: 22-8, 2015.
Artículo
en Inglés
| MEDLINE | ID: mdl-26757112
8.
The influence of dicoumarol on the bioactivation of the carcinogen aristolochic acid I in rats.
Mutagenesis
; 29(3): 189-200, 2014 May.
Artículo
en Inglés
| MEDLINE | ID: mdl-24598128
9.
Knockout and humanized mice as suitable tools to identify enzymes metabolizing the human carcinogen aristolochic acid.
Xenobiotica
; 44(2): 135-45, 2014 Jan.
Artículo
en Inglés
| MEDLINE | ID: mdl-24152141
10.
Dicoumarol inhibits rat NAD(P)H:quinone oxidoreductase in vitro and induces its expression in vivo.
Neuro Endocrinol Lett
; 35 Suppl 2: 123-32, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25638376
11.
Effect of dihydromyricetin on benzo[a]pyrene activation in rats.
Neuro Endocrinol Lett
; 35 Suppl 2: 158-68, 2014.
Artículo
en Inglés
| MEDLINE | ID: mdl-25638381
12.
Formation of DNA adducts by ellipticine and its micellar form in rats - a comparative study.
Sensors (Basel)
; 14(12): 22982-97, 2014 Dec 03.
Artículo
en Inglés
| MEDLINE | ID: mdl-25479328
13.
Mechanisms of enzyme-catalyzed reduction of two carcinogenic nitro-aromatics, 3-nitrobenzanthrone and aristolochic acid I: Experimental and theoretical approaches.
Int J Mol Sci
; 15(6): 10271-95, 2014 Jun 10.
Artículo
en Inglés
| MEDLINE | ID: mdl-24918288
14.
The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN™) mice and pure enzymes.
Int J Mol Sci
; 16(1): 284-306, 2014 Dec 25.
Artículo
en Inglés
| MEDLINE | ID: mdl-25547492
15.
Induced expression of cytochrome P450 1A and NAD(P)H:quinone oxidoreductase determined at mRNA, protein, and enzyme activity levels in rats exposed to the carcinogenic azo dye 1-phenylazo-2-naphthol (Sudan I).
Chem Res Toxicol
; 26(2): 290-9, 2013 Feb 18.
Artículo
en Inglés
| MEDLINE | ID: mdl-23289503
16.
The effect of benzo[a]pyrene on metabolic activation of anticancer drug ellipticine in mice.
Neuro Endocrinol Lett
; 34 Suppl 2: 43-54, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24362092
17.
Oxidation of carcinogenic benzo[a]pyrene by human and rat cytochrome P450 1A1 and its influencing by cytochrome b5 - a comparative study.
Neuro Endocrinol Lett
; 34 Suppl 2: 55-63, 2013.
Artículo
en Inglés
| MEDLINE | ID: mdl-24362093
18.
NAD(P)H:quinone oxidoreductase expression in Cyp1a-knockout and CYP1A-humanized mouse lines and its effect on bioactivation of the carcinogen aristolochic acid I.
Toxicol Appl Pharmacol
; 265(3): 360-7, 2012 Dec 15.
Artículo
en Inglés
| MEDLINE | ID: mdl-22982977
19.
Cytochrome b5 increases cytochrome P450 3A4-mediated activation of anticancer drug ellipticine to 13-hydroxyellipticine whose covalent binding to DNA is elevated by sulfotransferases and N,O-acetyltransferases.
Chem Res Toxicol
; 25(5): 1075-85, 2012 May 21.
Artículo
en Inglés
| MEDLINE | ID: mdl-22390216
20.
Pollen dispersal and gene flow within and into a population of the alpine monocarpic plant Campanula thyrsoides.
Ann Bot
; 110(7): 1479-88, 2012 Nov.
Artículo
en Inglés
| MEDLINE | ID: mdl-22718086